• 专利标题:   Preparing high-strength shape memory chitosan-based hydrogel comprises e.g. dissolving the chitosan in the acetic acid solution and stirring, adding citric acid and continue stirring to obtain a chitosan solution.
  • 专利号:   CN112430334-A, CN112430334-B
  • 发明人:   YUAN H, DU Q, XIONG F, LI B, XUAN H, YANG Y
  • 专利权人:   UNIV NANTONG
  • 国际专利分类:   A61L027/02, A61L027/20, A61L027/52, A61L027/56, C08J003/075, C08K003/04, C08K005/18, C08L005/08
  • 专利详细信息:   CN112430334-A 02 Mar 2021 C08J-003/075 202127 Pages: 7 Chinese
  • 申请详细信息:   CN112430334-A CN11264741 13 Nov 2020
  • 优先权号:   CN11264741

▎ 摘  要

NOVELTY - Preparing high-strength shape memory chitosan-based hydrogel comprises (i) dissolving the chitosan in the acetic acid solution and stirring for 4-6 hours, adding citric acid and continue stirring for 4-6 hours to obtain a chitosan solution, (ii) adding dopamine hydrochloride or graphene oxide or a mixture of the two to the chitosan solution and carrying pout ultrasonic reaction for 4-6 hours to obtain a chitosan-based solution with the concentration of 1-4 wt.%, (iii) injecting the chitosan-based solution into a mold, freezing for 8-24 hours, thawing it with lye, washing with deionized water to neutrality, demolding and freeze-drying. USE - The chitosan-based hydrogel is useful in minimally invasive implantation of medical material (claimed). ADVANTAGE - The hydrogel: has excellent mechanical property, shape memory function and wide application prospect; does not contain chemical components; adopts ethanol treatment, phosphate buffered saline solution or blood to fixed into the original shape. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) high-strength shape memory chitosan-based hydrogel prepared by the above mentioned; and (2) use method of minimally invasive implantation of medical material comprising (i) using ethanol to fixing the high-strength shape memory chitosan-based hydrogel into a fixed temporary shape hydrogel, the treatment time is 0.5-4 hours and the treatment temperature is at 20-50 degrees C, (ii) using water, phosphate buffered saline or blood to restoring the high-strength shape memory chitosan-based hydrogel processed in resultant step to the original shape of the high-strength shape memory chitosan-based hydrogel, the processing time is 20-300S and the processing temperature is room temperature.