• 专利标题:   Graphene nanopore sensor useful for evaluating a polymer molecule, comprises a substantially bare, single-layer graphene membrane, a connection, and an electrical circuit.
  • 专利号:   WO2011046706-A1, CA2772789-A1, AU2010307229-A1, EP2470899-A1, KR2012069720-A, US2012234679-A1, CN102630304-A, JP2013505448-W, IN201203356-P4, JP5612695-B2, CN102630304-B, JP2015014613-A, AU2010307229-B2, AU2016203366-A1, JP6054922-B2, EP2470899-B1, KR1732207-B1, BR112012005888-A2, EP3196645-A1, CA2772789-C, IN201948005982-A, EP3196645-B1, BR112012005888-B1
  • 发明人:   SLAVEN G, BRANTON D, GOLOVCHENKO J A, GOLOVCHENKO J, GARAJ S
  • 专利权人:   HARVARD COLLEGE, HARVARD COLLEGE, HARVARD COLLEGE, HARVARD COLLEGE
  • 国际专利分类:   C12Q001/68, G01N027/447, G01N033/487, G01N033/48, B82Y030/00, B82Y005/00, B82Y099/00, G01N027/453, G01N027/416, G01N027/06, G01N027/00
  • 专利详细信息:   WO2011046706-A1 21 Apr 2011 G01N-033/487 201129 Pages: 48 English
  • 申请详细信息:   WO2011046706-A1 WOUS049238 17 Sep 2010
  • 优先权号:   US243607P, US355528P, AU307229, CA2772789, US419383, KR709580, AU203366

▎ 摘  要

NOVELTY - A graphene nanopore sensor (10) comprises: a substantially bare, single-layer graphene membrane (14); a connection from the first graphene membrane surface to a first reservoir to provide a species in an ionic solution to the nanopore (12); a connection from the second graphene membrane surface to a second reservoir; and an electrical circuit connected on opposite sides of the nanopore to measure flow of ionic current through the nanopore in the graphene membrane. USE - The graphene nanopore sensor and method are useful for evaluating a polymer molecule (claimed). ADVANTAGE - The graphene nanopore sensor is highly sensitive, and has high resolution. DETAILED DESCRIPTION - A graphene nanopore sensor comprises: a substantially bare, single-layer graphene membrane including a nanopore extending through a thickness of the graphene membrane from a first graphene membrane surface to a second grapheme membrane surface opposite the first graphene membrane surface; a connection from the first graphene membrane surface to a first reservoir to provide, at the first graphene membrane surface, a species in an ionic solution to the nanopore; a connection from the second graphene membrane surface to a second reservoir to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first graphene membrane surface to the second graphene membrane surface; and an electrical circuit connected on opposite sides of the nanopore to measure flow of ionic current through the nanopore in the graphene membrane. INDEPENDENT CLAIMS are: (1) a nanopore sensor comprising: a solid state membrane having a thickness, between a first membrane surface and a second membrane surface opposite the first membrane surface, that is less than 1 nm; a nanopore extending through the membrane thickness between the first and second membrane surfaces and having a diameter that is greater than the membrane thickness; a connection from the first membrane surface to a first reservoir to provide, at the first membrane surface, a species in an ionic solution to the nanopore; a connection from the second membrane surface to a second reservoir to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first membrane surface to the second membrane surface; and an electrical circuit connected to monitor translocation of the species in the ionic solution through the nanopore in the solid state membrane; and (2) a method for evaluating a polymer molecule comprising: providing in an ionic solution a polymer molecule to be evaluated; translocating the polymer molecule in the ionic solution through a nanopore in a substantially bare, single-layer graphene membrane from a first graphene membrane surface to a second graphene membrane surface opposite the first graphene surface; and monitoring the flow of ionic current through the nanopore in the graphene membrane. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic perspective view of a graphene nanopore device. Graphene nanopore molecular characterization device (10) Nanopore (12) Bare, single-layer graphene membrane (14) Support frame (16) Support substrate (18) Molecules (20) Nucleoside bases (22) Silver chloride electrodes (24, 26)