• 专利标题:   Multi-functional integrated magnetic resonance contrast agent for magnetic resonance imaging, and treating reactive oxygen species-related diseases, comprises carbon fluoride nanomaterial as core, in which surface is provided with hydroxyl amino alcohols and nitrogen oxide free radicals.
  • 专利号:   CN115282295-A
  • 发明人:   LIU C, LUO L, LIU Y, LIU X, NIE Z, WANG X
  • 专利权人:   UNIV SICHUAN
  • 国际专利分类:   A61K031/4015, A61K031/473, A61K045/00, A61K047/52, A61K049/10, A61K049/18, A61P039/06, A61P009/00
  • 专利详细信息:   CN115282295-A 04 Nov 2022 A61K-049/10 202201 Chinese
  • 申请详细信息:   CN115282295-A CN10783012 24 Jun 2022
  • 优先权号:   CN10783012

▎ 摘  要

NOVELTY - Multi-functional integrated magnetic resonance contrast agent comprises carbon fluoride nanomaterial as core, in which the surface of the carbon fluoride nanomaterial is provided with hydroxyl amino alcohols and nitrogen oxide free radicals. USE - Multi-functional integrated magnetic resonance contrast agent for magnetic resonance imaging and diagnosis and treating reactive oxygen species-related diseases (claimed). ADVANTAGE - The contrast agent has good free radical stability and biological safety, and improved water dispersibility using amino alcohol, and is biocompatible and biosafety, DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing multifunctional integrated magnetic resonance contrast agent, which involves: preparing an ethanol dispersion of carbon fluoride nanomaterials to obtain an ethanol dispersion of carbon fluoride nanomaterials at -80 to 80℃; preparing the ethanol solution of nitroxide free radical and amino alcohol; adding dropwise an ethanol solution of nitroxide radicals to the ethanol dispersion of the fluorinated carbon nanomaterials to obtain a first reaction solution; dropwise adding the ethanol solution of the amino alcohol into the first reaction solution to obtain a second reaction solution; centrifuge and washing the second reaction solution, and drying the obtained precipitate to obtain a magnetic resonance contrast agent.