▎ 摘 要
NOVELTY - Electrically conductive hyaluronic acid-based hydrogel comprises a crosslinked porous scaffold formed from hyaluronic acid and having a graphene-based material encapsulated or in contact within the porous scaffold. USE - The hydrogel is useful for: culturing cells, where the cells comprise neural stem/progenitor cells (all claimed); and treating CNS tissue. No Biological data given. ADVANTAGE - The hydrogel utilizes hyaluronic acid which: is and does not elicit an immune response and in high molecular weight form has antiinflammatory properties; exhibits counteract glial scar formation after CNS injury by decreasing the size of the scar and the overall number of astrocytic glial cells; and provides a 3D microenvironment for encapsulated cells that has shear thinning properties, thus enabling safe delivery of the cultured cells to the injury site. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) an implanted bioelectronic device comprising many electrodes, polymer coated body and many metallic electrodes, where an electrically conductive hyaluronic acid-based hydrogel crosslinked into a porous scaffold is adhered to the polymer coated body, and where the porous scaffold contains a graphene-based material encapsulated in contact; and (2) culturing cells comprising providing the hydrogel that forms a porous scagffold having a graphene-based material encapsulated in contact within the porous scaffold, providing within, on, or adjacent to the porous scaffold, and applying electrical current through the porous scaffold.