• 专利标题:   Electrically conductive hyaluronic acid-based hydrogel used to e.g. culture cell e.g. neural stem cell comprises crosslinked porous scaffold formed from hyaluronic acid and having graphene-based material encapsulated within the scaffold.
  • 专利号:   US2021283312-A1
  • 发明人:   BIERMAN R
  • 专利权人:   UNIV CALIFORNIA
  • 国际专利分类:   A61N001/05, C08K003/04, A61L027/38, A61L027/34, A61L027/44, C08J003/075, A61L027/52
  • 专利详细信息:   US2021283312-A1 16 Sep 2021 A61L-027/52 202101 English
  • 申请详细信息:   US2021283312-A1 US198211 10 Mar 2021
  • 优先权号:   US988879P, US198211

▎ 摘  要

NOVELTY - Electrically conductive hyaluronic acid-based hydrogel comprises a crosslinked porous scaffold formed from hyaluronic acid and having a graphene-based material encapsulated or in contact within the porous scaffold. USE - The hydrogel is useful for: culturing cells, where the cells comprise neural stem/progenitor cells (all claimed); and treating CNS tissue. No Biological data given. ADVANTAGE - The hydrogel utilizes hyaluronic acid which: is and does not elicit an immune response and in high molecular weight form has antiinflammatory properties; exhibits counteract glial scar formation after CNS injury by decreasing the size of the scar and the overall number of astrocytic glial cells; and provides a 3D microenvironment for encapsulated cells that has shear thinning properties, thus enabling safe delivery of the cultured cells to the injury site. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) an implanted bioelectronic device comprising many electrodes, polymer coated body and many metallic electrodes, where an electrically conductive hyaluronic acid-based hydrogel crosslinked into a porous scaffold is adhered to the polymer coated body, and where the porous scaffold contains a graphene-based material encapsulated in contact; and (2) culturing cells comprising providing the hydrogel that forms a porous scagffold having a graphene-based material encapsulated in contact within the porous scaffold, providing within, on, or adjacent to the porous scaffold, and applying electrical current through the porous scaffold.