• 专利标题:   Jet in situ generated neural interface used for measuring the nerve signal, and for detecting the disease, comprises skin electrode and conductive self-connected electrode generated in situ from dispersion in skin.
  • 专利号:   CN113925518-A, CN113925518-B, WO2023045126-A1
  • 发明人:   WANG L, BI G, ZHAO G, CHENG Y, ZHAO S, SHA B, DU Z
  • 专利权人:   SHENZHEN INST ADVANCED TECHNOLOGY, SHENZHEN INST ADVANCED TECHNOLOGY
  • 国际专利分类:   A61B005/268, A61B005/294, A61B005/388, A61N001/04, A61N001/36, H01B001/14, H01B001/20, H01B013/00
  • 专利详细信息:   CN113925518-A 14 Jan 2022 A61B-005/388 202221 Chinese
  • 申请详细信息:   CN113925518-A CN11116073 23 Sep 2021
  • 优先权号:   CN11116073

▎ 摘  要

NOVELTY - The interface has a skin electrode detachably connected with a conductive self-connecting inner electrode. A patch electrode is selected from the patch electrode. The conductive particles are selected from metal nano-materials, carbon nano materials, MXene or modified conductive nanoparticles. The metal nanopaterials are chosen from silver nanopaterial, iron nanopaterial material, magnesium nanopaterial and/or aluminum nanopaterial. The carbon nano material is chosen from graphene and carbon nanotubes. The MXene is chosen as titanium carbide, titanium carbon dioxide, titanium chloride, niobium cobalt, vanadium carbide or cobalt-molybdenum carbide. The skin electrode is detachably fixedly connected with the conductive body-connected inner electrode, and the patch electrodes are selected as patch electrodes. USE - The jet in situ generated neural interface used for measuring the nerve signal, and for detecting the disease. It has good preventing and advanced diagnosis ability for inflammation of the nervous system, degenerative change and so on. It can also be used for afferent stimulation, common control muscle, stimulating the visual cortex, stimulating auditory cortex and stimulating the touch cortex. ADVANTAGE - The nerve interface implantation procedure has low complexity, small damage during the implantation process, small restriction on movement and high biocompatibility. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: 1. A system for preparing jet in situ generated neural interface, which comprises an electrically conductive self-connected electrode dispersion, an injection device and a skin electrode, the conductive self-connecting electrode dispersion comprises an isotonic dispersion and an external conductive particle comprising an adhesive layer, where the adhesive layer is a polydopamine layer and an oxidative polymerization bond-forming layer arranged successively at the exterior part of the electrically conductive particles; the oxidative polymerization bond-forming layer is selected from a polyethylene dioxythiophene layer, and a polypyrrole layer; the injection device is a pressure device for generating high pressure jet micro-water column; preferably, it is a jet injector, preferably, the concentration of conductive particles of the conductive self-connecting electrode dispersion comprises an adhesive layer is 0.1mg/ml-100mg/ml, 1mg/ml-50mg/ml, preferably Preferably, the isotonic dispersion is selected from the solution with concentration of 280 to 320mmol/l, Preferably, the conductive particles are selected from metal nano material, carbon nano material, MXene or any one of the modified conductive particles 2. A preparation method of the nerve interface generated by jet in situ, which involves using Michael addition reaction to polymerize dopamine: pre-polymerizing the dopamine in the alkaline buffer solution, and then mixing the pre-polymerization solution with the conductive particles to obtain conductive particles with polymerized dopamine layer, polymerizing in situ to obtain the oxidative polymerization bond-forming layer, the ethylene dioxythiophene raw material or pyrrole raw material is dispersed in the water-soluble organic solvent and adding in the aqueous solution of conductive particles of polymeric dopamine layer, under the condition of not containing the oxidant, obtaining the conductive particles having a polymeric dopamine layer and an external adhesive layer comprising an oxidation polymerization key layer. 3. A conductive self-connecting electrode dispersion liquid, which comprises n isotonic dispersion liquid and an external conductive particle comprising an adhesive layer; wherein the adhesive layer is a polydopamine layer and an oxidative polymerization bond-forming layer arranged successively at the exterior part of the electrically conductive particles, the oxidative polymerization bond-forming layer is selected from a polyethylene dioxythiophene layer, and a polypyrrole layer; Preferably, the concentration of the conductive particles of the conductive self-connecting electrode dispersion comprises an adhesive layer is 0.1mg/mL-100mg/mL, preferably 1mg/mL-50mg/mL; Preferably, the isotonic dispersion is selected from the solution with concentration of 280 to 320mmol/l, preferably, the conductive particles are selected from metal nano material, carbon nano material, MXene or any one of the modified conductive particles, more preferably, the metal nano material is selected from silver nano material, iron nano material, magnesium nano material, aluminium nano material, carbon nano material is selected from graphene, carbon nano tube, the MXene is selected from titanium carbide, niobium carbide, vanadium carbide, molybdenum carbide.. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of a jet injection device for conductive self-connecting dispersion liquid injection.