• 专利标题:   Modified graphene oxide drug-loaded delivery system comprises using graphene oxide as carrier to support drug X to obtain graphene oxide complex GO-X, the surface layer of the graphene oxide composite GO-X coated with polymeric ionic liquid.
  • 专利号:   CN108524940-A
  • 发明人:   WU H, LIU Y, HAN J, GUO Z, PAN C
  • 专利权人:   UNIV LIAONING
  • 国际专利分类:   A61K031/337, A61K031/352, A61K031/704, A61K047/04, A61K047/32, A61P035/00
  • 专利详细信息:   CN108524940-A 14 Sep 2018 A61K-047/04 201871 Pages: 11 Chinese
  • 申请详细信息:   CN108524940-A CN10412533 03 May 2018
  • 优先权号:   CN10412533

▎ 摘  要

NOVELTY - Modified graphene oxide drug-loaded delivery system comprises using graphene oxide as a carrier to support drug X to obtain a graphene oxide complex GO-X, the surface layer of the graphene oxide composite GO-X coated with a positively charged polymeric ionic liquid (PIL) and negatively charged polyacrylic acid (PAA) prepared PAA-PIL/GO-X. USE - The system is useful for preparing an antitumor drug (claimed). DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing modified graphene oxide drug delivery system comprising (1) dissolving drug X in a solvent under stirring, slowly adding dropwise to an aqueous solution of graphene oxide GO, and loading drug X onto the graphene oxide GO by ultrasonication, washing precipitate with solvent, and lyophilizing to obtain graphene oxide composite GO-X, (2) reconstituting GO-X, adding polymerized ionic liquid PIL solution at 45 degrees C under slow stirring, and mixing uniformly, reaction is stirred to obtain PIL/GO-X, (3) adding polyacrylic acid PAA solution dropwise to the PIL/GO-X solution under stirring, and stirring the reaction under heating at 45-70 degrees C for 1 hours, and reacting at room temperature for 12 hours to obtain PAA-PIL/GO-X.