• 专利标题:   System for analyzing of sample, where sample comprises bio-molecules comprises nano array, that comprises substrate, where substrate is glass, and multiple of plasmonic metal protrusions extending from substrate, where multiple of plasmonic metal protrusions is of plasmonic metal that is gold.
  • 专利号:   US2022136972-A1
  • 发明人:   YANG L, LEE K
  • 专利权人:   UNIV RUTGERS STATE NEW JERSEY
  • 国际专利分类:   C12Q001/6876, G01N021/65, G01N033/543
  • 专利详细信息:   US2022136972-A1 05 May 2022 G01N-021/65 202248 English
  • 申请详细信息:   US2022136972-A1 US512211 27 Oct 2021
  • 优先权号:   US107580P, US512211

▎ 摘  要

NOVELTY - System comprises a nanoarray, that comprises a substrate, where the substrate is glass, and multiple of plasmonic metal protrusions extending from the substrate, where the multiple of plasmonic metal protrusions is of a plasmonic metal that is gold, where the plasmonic metal in each of the multiple of plasmonic metal protrusions has a thickness in a range between 20-200 nm, where the multiple of plasmonic metal protrusions has a respective multiple of Graphene oxide (GO) nanosheet coatings layered there, where each of the GO nanosheet coatings has a lateral size in a range between 43-295 nm. USE - System for analysing of sample, where the sample comprises biochemical molecules selected from cells, cell-derived vesicles, RNA sequences, DNA sequences, pathogens, antigens, viruses, and viral particles (all claimed). ADVANTAGE - The system provide graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electro- magnetic mechanism and chemical mechanism based signal enhancement for achieving sensitive and reproducible detectopn of Raman singals. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: 1. a system (100), which comprises a nano array (101), comprises a substrate, an incident light source (103), detector (105), and a processor (107); and 2. a method which involves: a. disposing a sample onto multiple of plasmonic metal protrusions extending from a substrate, where the multiple of plasmonic metal protrusions has a respective multiple of graphene oxide, nanosheet coatings, where the sample comprises biochemical molecules that are coupled to a portion of the multiple of plasmonic metal protrusions; b. labeling the biochemical molecules in the sample with a Raman dye; c. illuminating the multiple of plasmonic metal protrusions with a light directed from an incident light source having one excitation frequency, where the biochemical molecules emit one Surface enhanced Raman scattering (SERS) light in response to the light being directed onto the multiple of plasmonic metal protrusions from the incident light source; d. detecting, by a detector, one laser power intensity and one Raman shift in vibrational wave number of the Raman dye of the one SERS spectra in a SERS spectra; e. increasing a Signal-to-noise ratio (SNR) of the one SERS spectra above SNR predefined threshold by varying a thickness of a plasmonic metal in the multiple of plasmonic metal protrusions to be within a range between 20-200 nm; f. varying a lateral size of each of the GO nanosheet coatings to be within a range between 43-95 nm, and choosing a composition of the Raman dye to have a Raman cross-section value at the one excitation frequency greater than 3x1014 Hz; g. receiving, by a processor, from the detector, data about the one Raman shift in vibrational wave number of the one SERS spectra, the one laser power intensity of the one SERS spectra, or its combination; and h. identifying, by the processor, the biochemical molecules in the sample based on the one Raman shift in vibrational wave number of the one SERS spectra, the one laser power intensity of the one SERS spectra, or its combination. DESCRIPTION OF DRAWING(S) - The drawing shows a system. System (100) Nano array (101) Incident light source (103) Detector (105) Processor (107)