• 专利标题:   Reagent used for fast detection of mitoxantrone or adriamycin, comprises solution containing chromone Schiff base prepared using graphene quantum dot aqueous solution, catalyst, alcohol solution of chromone compound, and mixed solvent.
  • 专利号:   CN115290608-A
  • 发明人:   LIU B, SUN W, QI L, ZHOU C, TANG S, QIAN L, WANG Z, CHENG R
  • 专利权人:   UNIV WENZHOU MEDICAL
  • 国际专利分类:   G01N021/64
  • 专利详细信息:   CN115290608-A 04 Nov 2022 G01N-021/64 202204 Chinese
  • 申请详细信息:   CN115290608-A CN11578965 22 Dec 2021
  • 优先权号:   CN11578965

▎ 摘  要

NOVELTY - A reagent comprises a solution containing a chromone Schiff base. The chromone Schiff base is prepared by adding 0.1-20 mg/mL graphene quantum dot aqueous solution into a container, uniformly stirring the solution at a constant speed, adding catalyst, gradually adding an alcohol solution of a chromone compound, heating at 45-80°C for 2-24 hours, and dialyzing the obtained product in a mixed solvent for three days using a dialysis bag having a molecular weight of 1000 Da. USE - Reagent for fast detection of mitoxantrone or adriamycin (all claimed) used for treating acute leukemia, breast cancer, prostate cancer, lymphoma and multiple sclerosis. ADVANTAGE - The reagent is simple, and has high selectivity for mitoxantrone and adriamycin. The detection method is simple, convenient, practical and easy, ensures high sensitivity, and quickly detects mitoxantrone or adriamycin at normal temperature in aqueous environment. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for fast detection of mitoxantrone or adriamycin, which involves adding the reagent and 10-8M to 10-3M substance to be tested, and testing by fluorescence photometry in which fluorescence spectrum of the test solution is at EM 409 nm.