• 专利标题:   Hydrogel used in e.g. medicine, veterinary or cosmetic, material and article e.g. medical device, cartilage substitute, intervertebral disc, catheter, vascular graft and stent includes poly(2-hydroxyethyl methacrylate) and graphene material.
  • 专利号:   WO2019197504-A1
  • 发明人:   TRINDADE PEREIRA A S, DOMINGOS DE MONTENEGRO BAPTIST, DE CASTRO GONCALVES DE ALMADA
  • 专利权人:   INEBINST ENG BIOMEDICA, UNIV DO PORTO
  • 国际专利分类:   A61K047/06, C08F220/20, C08K003/04
  • 专利详细信息:   WO2019197504-A1 17 Oct 2019 C08F-220/20 201983 Pages: 45 English
  • 申请详细信息:   WO2019197504-A1 WOEP059168 10 Apr 2019
  • 优先权号:   PT110678

▎ 摘  要

NOVELTY - Hydrogel comprises poly(2-hydroxyethyl methacrylate) and at least 1 wt.% of graphene material, where the oxidation degree of the graphene material is 10-50% (oxygen atomic percentage). USE - The hydrogel is useful in medicine, veterinary or cosmetic, a material and an article comprising a medical device, preferably a cartilage substitute, an intervertebral disc, a catheter, a vascular graft, a heart valve, a stent, an artificial kidney, an artificial lung, a ventricular assist device, a contact lenses, a keratoprosthesis or a scaffold (all claimed), and soft robotics, packaging, sealing and sensors. ADVANTAGE - The hydrogel: exhibits extreme stiffness, high-strength, water absorption capacity, surface wettability and biocompatibility; maintains the non-fouling properties (low protein and cell adhesion); and specifies a non-effect in surface features of poly(2-hydroxyethyl methacrylate) upon graphene material incorporation previous studies showed that graphene nanoplatelets incorporation in polylactide increased its surface hydrophobicity and reduced platelet activation in the presence of plasma proteins, while incorporation of graphene oxide in polyetherimide increased its hydrophilicity and prevents platelets adhesion.