▎ 摘　　要

NOVELTY - Preparing a graphene oxide composite material with a multi-arm polyethylene glycol and a sulfhydryl group connected by a covalent bond involves activating the carboxyl groups on the graphene oxide sheet to obtain a graphene oxide dispersion. The graphene oxide dispersion is mixed with a multi-arm polyethylene glycol with an amino end group, a condensation agent. The water-soluble strong base and cysteamine are mixed uniformly, heated to 50-100 degrees C, reacted for 6-24 hours, and then separated. USE - Method for preparing a graphene oxide composite material with a multi-arm polyethylene glycol and a sulfhydryl group used as a nano-drug carrier platform with targeted and controlled release effects (Claimed). ADVANTAGE - The method enables to prepare a graphene oxide composite material with a multi-arm polyethylene glycol and a sulfhydryl group has excellent dispersion stability and biocompatibility in water, load water-insoluble anti-cancer drugs through disulfide bonds, and has a controlled release effect. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a graphene oxide composite material with multi-arm polyethylene glycol and sulfhydryl groups connected by covalent bonds represented by formula (I), where the number of arms of multi-arm polyethylene glycol is 4, 6 or 8, and n is an integer of 10-20; and (2) a method for loading anticancer drugs with graphene oxide composite material of covalently connecting sulfhydryl and multi-arm polyethylene glycol, which involves dispersing the graphene oxide composite material covalently connected with sulfhydryl groups and multi-arm polyethylene glycol in deionized water; mixing with modified anticancer drugs and react at room temperature for 6-24 hours; obtaining the graphene oxide composite material loaded with anticancer drugs by filtration and separation.