• 专利标题:   Graphene channel member useful in biosensor for detecting biocide e.g. polyhexamethyleneguanidine, comprises graphene film and nanovesicle comprising transient receptor potential cation channel, subfamily A, member 1 immobilized on graphene film.
  • 专利号:   WO2021194207-A1, KR2021118671-A, KR2504692-B1
  • 发明人:   KWON O S, SONG H S, KIM W K, KWAK J S, KIM K H, KIM D H, KIM J Y, PARK S J, PAK Y S, PARK C S, SEO S E, RYU Y S, YOON S J, LEE S W, LEE J Y, KWONOSUK, SEOK S H, KIM W G, JISUNG K, KIM J, PARK S, YOOSIN P, SEONGEUN S, SANG R Y, YOON S, SANGWOO L
  • 专利权人:   KOREA RES INST BIOSCIENCE BIOTECHNOLOG, KOREA INST SCI TECHNOLOGY, KOREA RES INST CHEM TECHNOLOGY
  • 国际专利分类:   G01N033/544, G01N033/554, G01N033/543, G01N027/414
  • 专利详细信息:   WO2021194207-A1 30 Sep 2021 202193 Pages: 37
  • 申请详细信息:   WO2021194207-A1 WOKR003555 23 Mar 2021
  • 优先权号:   KR035224

▎ 摘  要

NOVELTY - Graphene channel member comprises a graphene film and a nanovesicle immobilized on the graphene film, where the nanovesicle comprises a transient receptor potential cation channel, subfamily A, member 1 (TRPA1). USE - The graphene channel member is useful in biosensor for detecting biocide such as polyhexamethyleneguanidine (PHMG), 2-bromo-2-nitropropane-1,3-diol (BNP), 2-octyl-3 (2H)-isothiazolone (OIT), chloromethylisothiazolinone (CMIT) , methylisothiazolinone (MIT), citric acid (CA), carbendazim (CBDZ), sodium 2-pyridinethiol 1-oxide (SPO), iodopropynyl butylcarbamate (IPBC) and didecyldimethylammonium chloride (DDAC) (all claimed) in household chemical products such as insecticide, and deodorant, or processed foods. ADVANTAGE - The graphene channel member selectively reacts with a biocide and thus simply detects biocide with high sensitivity, and detects even a very small amount of a biocide with a concentration of about 10 mu g/l. The graphene channel member has improved stability of attachment and fixation of nanovesicles and excellent electrical conductivity through surface modification. The graphene transistor has excellent portability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) graphene transistor comprising board, the graphene channel member and a pair of electrodes; (2) biosensor comprising graphene transistor; and (3) method for detecting a biocide from a sample involves processing the sample in the biosensor and measuring an electrical signal of the biosensor.