▎ 摘　　要

NOVELTY - Preparation of graphene medicine carrier material comprises mixing graphite powder, concentrated sulfuric acid, potassium persulfate and phosphorus pentoxide, reacting, diluting with water, filtering and washing; drying preproduct overnight, adding concentrated sulfuric acid and potassium permanganate, reacting, diluting, boiling, adding water and hydrogen peroxide solution, precipitating; filtering precipitate, washing with diluted hydrochloric acid, washing with water, dialyzing to obtain graphite oxide, ultrasonic peeling and preparing graphene oxide stock solution; dissolving trivalent iron salt and hexamethylene tetramine into glycol solution, adding stock solution, ultrasonic dispersing, hydrothermal reacting, cooling, separating magnetic substance, repeatedly washing and separating, and drying separated material to obtain magnetic graphite nanocomposite; and dispersing nanocomposite in aqueous solution, adding cationic surfactant, adjusting pH, adding organosilane and reacting. USE - Method for preparing graphene medicine carrier material. ADVANTAGE - The method is simple and low cost. The carrier material has large specific surface area, magnetic fluorescent biocompatibility and improved biocompatibility and photothermal absorption performance, which reduces adverse reaction and increases medicine loading and stability. DETAILED DESCRIPTION - Preparation of graphene medicine carrier material comprises mixing 1-3 pts. wt. graphite powder, 20-30 pts. wt. concentrated sulfuric acid, 2-3 pts. wt. potassium persulfate and 2-3 pts. wt. phosphorus pentoxide, reacting at 60-70 degrees C for 4-5 hours, adding 450-550 pts. wt. water to dilute, filtering and washing to remove excess acid; drying preproduct overnight at room temperature, adding 80-120 pts. wt. concentrated sulfuric acid, gradually adding 10-14 pts. wt. potassium permanganate in ice water bath, reacting mixture at 30-50 degrees C, stirring for 20-40 minutes, reacting at 70-90 degrees C for 1-3 hours, adding water to dilute, boiling and reacting for 30 minutes, stirring for 0.5-1.5 hours, adding 500 pts. wt. water and 20 pts. wt. 30% hydrogen peroxide solution and standing to precipitate for 3-5 hours; filtering precipitate, washing with 1:10 diluted hydrochloric acid for 5 times, washing with water until neutral, subjecting obtained product to dialysis purification to remove residual metal ions to obtain graphite oxide, ultrasonic peeling for 20-40 minutes at room temperature condition and preparing 0.5 mg/mL graphene oxide stock solution; dissolving trivalent iron salt and hexamethylene tetramine into glycol solution, adding graphene oxide stock solution, ultrasonic dispersing for 30-50 minutes, transferring into hydrothermal reaction kettle, reacting at 170-210 degrees C for 8-10 hours, cooling to room temperature, separating magnetic substance from solution using magnet, repeatedly washing with water and absolute ethanol, separating by magnet and drying separated magnetic graphite material to obtain magnetic graphite nanocomposite; and dispersing graphene magnetic nanocomposite in aqueous solution, adding cationic surfactant, adjusting pH value to 10-12, adding organosilane and reacting at room temperature for 20-30 hours to obtain carrier material.