• 专利标题:   Nanoparticle useful for generating theranostic nanoparticles for treating or preventing cancer in human subject, comprises reduced graphene sheet, chitosan, MRI contrast agent, chemotherapeutic agent and DNA plasmid.
  • 专利号:   US9675714-B1
  • 发明人:   MOHAPATRA S, WANG C
  • 专利权人:   UNIV SOUTH FLORIDA, MOHAPATRA S, WANG C
  • 国际专利分类:   A61K031/704, A61K048/00, A61K049/00, A61K049/18, A61K051/00, A61M036/14
  • 专利详细信息:   US9675714-B1 13 Jun 2017 A61K-051/00 201744 Pages: 29 English
  • 申请详细信息:   US9675714-B1 US186845 21 Feb 2014
  • 优先权号:   US767572P, US186845

▎ 摘  要

NOVELTY - Nanoparticle comprises a reduced graphene sheet, and chitosan, a MRI contrast agent, a chemotherapeutic agent, and a DNA plasmid which are attached to or loaded onto the reduced graphene sheet. USE - The nanoparticle is useful for generating theranostic nanoparticles (claimed), simultaneously delivering a diagnostic moiety, drug moiety, and a gene therapy moiety, or treating, or preventing cancer in a subject. The subject is human. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) theranostic formulation comprising above-mentioned nanoparticle and a carrier; and (2) method for generating theranostic nanoparticles involves reducing a graphene oxide sheet to form reduced graphene oxide sheet, and loading or attaching MRI contrast agent, chitosan, a chemotherapeutic agent, and DNA plasmid moiety onto the reduced graphene oxide sheet.