• 专利标题:   Preparing graphene oxide-titanium dioxide-hypocrellin ternary composite system used for preparing medicine for photodynamic therapy, involves oxidizing graphene by using strong oxidizing agent to obtain product.
  • 专利号:   CN105412925-A
  • 发明人:   DING Y, WEI S, ZHOU J, ZHOU L, CHEN E
  • 专利权人:   UNIV NANJING NORMAL
  • 国际专利分类:   A61K041/00, A61K047/48, A61P035/00
  • 专利详细信息:   CN105412925-A 23 Mar 2016 A61K-041/00 201644 Pages: 8 English
  • 申请详细信息:   CN105412925-A CN10800911 19 Nov 2015
  • 优先权号:   CN10800911

▎ 摘  要

NOVELTY - Preparing graphene oxide-titanium dioxide-hypocrellin ternary composite system involves oxidizing graphene by using strong oxidizing agent to obtain a product. Product is washed with hydrochloric acid and dispersed in distilled water to obtain graphene oxide aqueous solution with negative electricity surface. Titanium dioxide nano particle aqueous solution with positive electricity surface is prepared by using sol-gel method. Graphene oxide (GO) is mixed with distilled water and hypocrellin (HA) at constant temperature for 24 hours to form HA-GO compound. USE - Method for preparing graphene oxide-titanium dioxide-hypocrellin ternary composite system used for preparing medicine for photodynamic therapy (all claimed). ADVANTAGE - The method increases active oxygen producing capacity of hypocrellin, enables to prepare raphene oxide-titanium dioxide-hypocrellin ternary composite system has low toxicity and improved dispersibility. DETAILED DESCRIPTION - Preparing graphene oxide-titanium dioxide-hypocrellin ternary composite system involves oxidizing graphene by using strong oxidizing agent to obtain a product. Product is washed with hydrochloric acid and dispersed in distilled water to obtain graphene oxide aqueous solution with negative electricity surface. Titanium dioxide nano particle aqueous solution with positive electricity surface is prepared by using sol-gel method. Graphene oxide (GO) is mixed with distilled water and hypocrellin (HA) at constant temperature for 24 hours to form HA-GO compound. Titanium dioxide nano particle aqueous solution is mixed with HA-GO compound at constant temperature for 24 hours, centrifuged, washed, and carried out dialysis to prepare aqueous phase and stable graphene oxide-titanium dioxide-hypocrellin ternary composite system.