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  • 专利标题:   Preparing carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel involves adding chitosan into weak acid solution of graphene oxide, and adding N-isopropyl acrylamide monomer and photoinitiator.
  • 专利号:   CN107540883-A
  • 发明人:   YU J, CHEN Y, HU Z, WANG Y, ZHU J, SONG Y
  • 专利权人:   UNIV DONGHUA
  • 国际专利分类:   C08F120/54, C08F002/48, C08F220/54, C08F222/38, C08J003/075, C08J003/24, C08J003/28, C08K003/04, C08L033/24, C08L005/08
  • 专利详细信息:   CN107540883-A 05 Jan 2018 C08L-005/08 201813 Pages: 15 Chinese
  • 申请详细信息:   CN107540883-A CN10804047 08 Sep 2017
  • 优先权号:   CN10804047

▎ 摘　　要

NOVELTY - Preparing carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel involves adding chitosan into weak acid solution of graphene oxide and stirring uniformly at room temperature. The N-isopropyl acrylamide monomer and photoinitiator are added and stirred uniformly to obtain carboxymethyl chitosan/graphene oxide/N-isopropyl acrylamide dispersion. 1-(3-Dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide is added to carboxymethyl chitosan/graphene oxide/N-isopropylacrylamide dispersion to obtain a mixed solution. USE - Method for preparing carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel. ADVANTAGE - The method enables to prepare carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel that has good biocompatibility in drug release, molecular devices and potential applications. The nano composite hydrogel has double-response characteristic of pH/activity temperature. DETAILED DESCRIPTION - Preparing carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel involves adding chitosan into weak acid solution of graphene oxide and stirring uniformly at room temperature. The N-isopropyl acrylamide monomer and photoinitiator are added and stirred uniformly to obtain carboxymethyl chitosan/graphene oxide/N-isopropyl acrylamide dispersion. 1-(3-Dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide is added to carboxymethyl chitosan/graphene oxide/N-isopropylacrylamide dispersion at room temperarure under stirring to obtain a mixed solution. The mixed solution is reacted under nitrogen atmosphere at room temperature to obtain chitosan/graphene oxide crosslinking solidified hydrogel. The carboxymethyl chitosan/graphene crosslinked cured hydrogel is placed in a water bath and irradiated ultraviolet light having wavelength of 365 nanometer to obtain carboxymethyl chitosan/graphene oxide/poly (N-isopropyl acrylamide) nano-composite hydrogel.