▎ 摘　　要

NOVELTY - Graphene/silver nanometer/ poly(methyl methacrylate) (PMMA) sandwich structured flexible surface-enhanced Raman scattering (SERS) substrate comprises monolayer graphene, silver nanoparticles and PMMA films. USE - Graphene/silver nanometer/ poly(methyl methacrylate) (PMMA) sandwich structured flexible surface-enhanced Raman scattering (SERS) substrate used for in situ trace detection in biosensor (claimed). DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for the preparation of graphene/silver nanometer/ poly(methyl methacrylate) (PMMA) sandwich structured flexible surface-enhanced Raman scattering (SERS) substrate comprising growing monolayer of graphene on copper foil, growing layer of silver nanoparticles on the surface of single graphene by micro current assisted chemical reduction, covering layer of PMMA film on silver nano layer and etching to remove copper foil.