▎ 摘　　要

NOVELTY - The device has an agent carrier comprises an agent transfer surface for non-invasive delivery of an agent into a tissue, and a multiple nanoscale channels extending partially or wholly through the agent carrier to the agent transfer surface enabling retention of the agent and/or transportation of the agent to the tissue. The agent carrier comprises or is acoustically couplable to a piezoelectric substrate. An electrode is electrically couplable to the piezoelectric substrate. A controller is electrically couplable to the electrode and configured to apply an electrical signal to the electrode to propagate an acoustic wave on and/or in the piezoelectric substrate which is capable of delivering the agent from the agent carrier into the tissue. The multiple nanoscale channels is fabricated using silicon, porated silicon, germanium, graphene, synthetic polymer or a combination. USE - Device for non-invasive delivery of agents such as pharmaceuticals into and across biological tissues using ultrasound and nanoporous carriers. ADVANTAGE - The method provides non-invasive delivery of agents into biological tissues using a combination of ultrasound and nanoporous carriers. The use of agent carriers having a high density of nanoscale features increases the surface area to volume ratio of such agent carriers. This reduces the weight of an agent carrier and reduces the power needed to achieve the desired sonophoretic (i.e. ultrasound-mediated) effect for delivery of the agent through tissue, and may thus reduce the heat and stress applied to the tissue. Additionally, the high surface area of nano-scale porous features increase the radiating contact area of ultrasound again reducing the amount of power required to facilitate delivery via sonophoresis and making the process less disruptive to the treated tissue. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for delivering an agent to an internal layer within a target tissue. DESCRIPTION OF DRAWING(S) - The drawing shows a cross-sectional view of the applicator device.