▎ 摘　　要

NOVELTY - Functionalized biomimetic nanomaterial comprises a degradable two-dimensional nanomaterial, a biomimetic biological coating with an anti-nonspecific adhesion function combined on two-dimensional nanomaterial, and a dendrite with an alkyne group modified at the end loaded on biomimetic biological coating cationic polymer. The biomimetic biological coating is an antifouling hydrophilic polymer whose terminal is modified with phenyl, amino, catechol and azido groups, and phenyl, amino and catechol group used as an anchor region to combine with two-dimensional nanomaterial, and the azide group reacts with the alkyne group modified at the end of dendritic cationic polymer. USE - Functionalized biomimetic nanomaterial used in preparing medicines for specifically neutralizing circulating free nucleic acids (claimed). ADVANTAGE - The biomimetic nanometer materia has good tissue compatibility, systemic intravenous administration, high biological safety, simple operation, low cost, less toxic and side effects, and good material stability. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing the functionalized biomimetic nanomaterial, which involves preparing two-dimensional nanomaterials from crystal materials under the protection of protective gas, preparing the anti-fouling hydrophilic polymer P, modifying the azide group at the end of anti-fouling hydrophilic polymer to obtain an azide polymer N3-P, and then N3-P modified with amino group, phenyl group and catechol group to obtain biomimetic biological coating N3-P-CatPh, modifying the alkynyl group at the end of dendritic cationic polymer to obtain a dendritic cationic polymer modified with an alkynyl group at end, mixing the biomimetic biological coating with two-dimensional nanomaterial amino group, phenyl group and catechol group on the biomimetic biological coating serve as anchoring regions to allow the biomimetic biological coating layer stably combined on the surface of two-dimensional nanomaterial to obtain a biomimetic coated two-dimensional nanomaterial, mix the nanomaterials with dendritic cationic polymers modified with alkyne groups at the end, performing a click chemical reaction to complete the surface dendritic cation modification, and purifying to obtain the functionalized biomimetic nanomaterials, alternatively, mixing and purifying the two-dimensional nanomaterial, the biomimetic coating and the dendritic cationic polymer to obtain a functionalized biomimetic nanomaterial.