• 专利标题:   Preparing dopamine-sensitive sensor comprises preparing solution comprising graphene oxide, 3,4-ethylenedioxythiophene, and polystyrene sulfonate, and immersing, in the solution, the electrodes and applying current to deposit.
  • 专利号:   US2022381722-A1, KR2022159183-A
  • 发明人:   KO S, LEE Y J, LEEYIJAE, KOH S
  • 专利权人:   KOREA INST SCI TECHNOLOGY, KOREA INST SCI TECHNOLOGY
  • 国际专利分类:   B82Y030/00, G01N027/30, G01N027/327, G01N027/48, G01N033/483
  • 专利详细信息:   US2022381722-A1 01 Dec 2022 G01N-027/327 202202 English
  • 申请详细信息:   US2022381722-A1 US747354 18 May 2022
  • 优先权号:   KR067218

▎ 摘  要

NOVELTY - Preparing dopamine-sensitive sensor comprises preparing solution comprising graphene oxide (GO), 3,4-ethylenedioxythiophene (EDOT), and polystyrene sulfonate (PSS), and immersing, in the solution, electrodes having a reference electrode, a counter electrode, and a working electrode formed on a support, and applying current to the working electrode to selectively deposit GO/PEDOT:PSS, where the solution comprises 0.0003-0.0015 mol EDOT relative to 1 g of GO, and the molar ratio of EDOT and PSS is 1:7-13. USE - The method is useful for: preparing dopamine-sensitive sensor useful for diagnosing an abnormal dopamine secretion-related disease e.g. depression, schizophrenia, attention deficit/hyperactivity disorder (ADHD), psychosis, or Parkinson's disease (all claimed). ADVANTAGE - The method provides quantitative analysis of dopamine at excellent selectivity and high linearity with concentrations even in the presence of interfering substances. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) dopamine-sensitive sensor equipped with electrodes having a reference electrode, a counter electrode, and a working electrode formed on a support, the working electrode comprising a selectively deposited GO/PEDOT:PSS layer, where the GO/PEDOT:PSS layer comprises 0.0003-0.0015 mol EDOT relative to 1 g of GO, and the molar ratio of EDOT and PSS is 1:7-13; (2) detecting dopamine, comprising bringing the electrodes of the sensor into contact with dopamine-containing sample to perform differential pulse voltammetry (DPV); and (3) providing information for diagnosing an abnormal dopamine secretion-related disease, comprising quantitatively analyzing a sample by using the method for detecting dopamine, the sample being isolated from a subject suspected of abnormal dopamine secretion.