• 专利标题:   Point-of-care diagnostic system for determining amount of phenylalanine in blood, has electronic device that is configured to measure data of electrochemical changes occurring due to amount of phenylalanine included in blood specimen and to provide data as numerical value.
  • 专利号:   WO2023121632-A2
  • 发明人:   DUMAN M, ELBUKEN C, BAS D, AKYILMAZ I
  • 专利权人:   UNIV BILKENT ULUSAL NANOTEKNOLOJI ARASTI
  • 国际专利分类:   G01N000/00
  • 专利详细信息:   WO2023121632-A2 29 Jun 2023 G01N-000/00 202356 Pages: 25 English
  • 申请详细信息:   WO2023121632-A2 WOTR051572 22 Dec 2022
  • 优先权号:   TR020698

▎ 摘  要

NOVELTY - The system (1) has a cartridge (2) that separates a blood specimen into plasma and dripped so as to perform electrochemical measurement. A centrifugation device (3) is configured to apply centrifugation transaction to the cartridge in order to make the blood specimen that is dripped onto the cartridge, and is made ready for electrochemical measurement by separating the blood specimen into the plasma. An electronic device (4) is in connection with the cartridge, and configured to measure data of electrochemical changes occurring due to amount of phenylalanine included in the blood specimen and to provide the data as a numerical value. A nicotinamide adenine dinucleotide reagent and a phenylalanine dehydrogenase (PDH) enzyme perform an electrochemical reaction with blood plasma using electrochemical methods in form of amperometry or voltammetry are added. An upper layer is made of a blood-compatible material preferably by polymethylmethacrylate (PMMA). USE - Point-of-care diagnostic system e.g. lab-on-a-CD system (claimed) for determining amount of phenylalanine in blood by performing rapid blood analysis for early diagnosis and follow-up of phenylketonuria disease in community health center in smallest residential area. ADVANTAGE - The point-of-care diagnostic system does not require sample storage and transportation for phenylalanine measurement from the blood, and provides highly-accurate results in a short time. DESCRIPTION OF DRAWING(S) - The drawing shows the schematic view of the point-of-care diagnostic system. 1Point-of-care diagnostic system 2Cartridge 3Centrifugation device 4Electronic device