▎ 摘　　要

NOVELTY - Graphene oxide surface-modified metal nanorod cluster comprises a electronegative charge polymer and a temperature-responsive polymer. The metal nanorod is combined to the electronegative polymer and electrostatic interaction of the copolymer. The Raman reporter is adhered to Gold nanorod. USE - Graphene oxide surface-modified metal nanorod cluster for surface enrichment Raman scattering (SERS) base biosensing or the bioimage measurement (claimed). ADVANTAGE - The graphene oxide surface-modified metal nanorod cluster provides solubility and more excellent stability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a manufacturing method of the graphene oxide-metal nanorod cluster, which involves modifying the surface of the graphene oxide with a copolymer comprising a negative charge polymer and a temperature-responsive polymer; mixing the surface-modified graphene oxide with the Raman reporter-attached metal nano-rods to obtain a graphene oxide-metal nano-rod cluster for surface-enhanced Raman scattering-based biosensing or bioimaging; and (2) a method for preparing magnetic nanoparticle-antigen immunoconjugate, which involves reacting the magnetic nanoparticle conjugated with an antibody specific for an antigen and the antigen to produce a magnetic nanoparticle-antigen immunoconjugate; and contacting the magnetic nanoparticle-antigen immunoconjugate with an antibody specific for the antigen, and irradiating the sandwich immunocomplex with laser light to measure a surface enhanced Raman scattering signal.