• 专利标题:   Electronic biological sample analysis system for biological sample analysis, e.g. DNA sequencing and blood chemistry analysis, comprises biological sample sensor comprising transistors comprising graphene and sample well.
  • 专利号:   US2015307936-A1, WO2016164783-A1, US9765395-B2, IN201717039322-A, EP3280822-A1, EP3280822-A4
  • 发明人:   GOLDSMITH B
  • 专利权人:   NANOMEDICAL DIAGNOSTICS INC, NANOMEDICAL DIAGNOSTICS INC
  • 国际专利分类:   C12Q001/68, G01N027/414, H01L027/088, H01L029/72, C12Q001/6869, C12Q001/6874
  • 专利详细信息:   US2015307936-A1 29 Oct 2015 C12Q-001/68 201576 Pages: 34 English
  • 申请详细信息:   US2015307936-A1 US684283 10 Apr 2015
  • 优先权号:   US263954, US684283, WOUS026730

▎ 摘  要

NOVELTY - Electronic biological sample analysis system for biological sample analysis comprises a biological sample sensor comprising transistors, where at least one transistor comprises graphene and where electrical properties of the transistor change in response to contact with a DNA sequence; and a sample well having a bottom portion, where the sample well is in fluidic communication with the biological sample sensor. USE - The system or method is useful for biological sample analysis (claimed), e.g. DNA sequencing and blood chemistry analysis. ADVANTAGE - In the method, the changes in electrical properties are analyzed to determine the presence of binding DNA subjugates based on the changes in pH associated with such binding process. This technique can be extraordinarily sensitive, and can be engineered to tailor the sensitivity of the electronic circuit system to obtain desired measurements. DETAILED DESCRIPTION - Electronic biological sample analysis system for biological sample analysis comprises a biological sample sensor comprising transistors, where at least one transistor comprises graphene and where electrical properties of the transistor change in response to contact with a DNA sequence; and a sample well having a bottom portion, where the sample well is in fluidic communication with the biological sample sensor; or electronic biological sample analysis system for biological sample analysis comprises a sensing section including a sensor chip comprising transistors and sequencing probes, where at least one of the transistors comprises graphene; a plate section including a biological sample well, where the biological sample well is in fluidic communication with the sensor chip; and a processing section including a processing module. An INDEPENDENT CLAIM is a method for biological sample analysis comprising introducing a biological sample into a sample well, the sample well comprising a sensor; applying a voltage to the sensor, where the sensor comprises sequencing probes and graphene transistors; measuring an electrical property of the sensor; identifying changes in the electrical property; identifying a change in pH of the suspension based on the change in the electrical property; and identifying a DNA sequence present in the suspension based on the change in pH.