• 专利标题:   Biodegradable nanofiber medical bandage comprises support layer obtained by arranging ordinary gauze with hydrophobic finishing agent, and repair layer comprising nanofibers with skin-core structure formed on upper surface of support layer.
  • 专利号:   CN112315660-A, CN112315660-B
  • 发明人:   LIAN Z
  • 专利权人:   GUANGZHOU MULANCHUN BIOTECHNOLOGY CO LTD, XINLEJIA BIOTECHNOLOGY WENZHOU CO LTD
  • 国际专利分类:   A61F013/00, D01D005/34, D01F001/10, D01F008/16, D06M013/148, D06M013/292, D06M015/643
  • 专利详细信息:   CN112315660-A 05 Feb 2021 A61F-013/00 202122 Pages: 15 Chinese
  • 申请详细信息:   CN112315660-A CN11535601 23 Dec 2020
  • 优先权号:   CN11535601

▎ 摘  要

NOVELTY - A biodegradable nanofiber medical bandage comprises a support layer and a repair layer. The support layer is obtained by arranging ordinary gauze with a hydrophobic finishing agent, and constructing a repair layer on the upper surface of the support layer. The repair layer comprises nanofibers with a skin-core structure. USE - Biodegradable nanofiber medical bandage. ADVANTAGE - The biodegradable nanofiber medical bandage has long storage time and excellent antibacterial performance. When biodegradable nanofiber medical bandage is in use, the nanofiber absorbs the excess blood tissue fluid to keep the wound environment clean and avoid the growth of bacteria. When the bandage absorbs the tissue fluid and blood secreted from the wound, the change of pH value triggers the hydrolysis of the melon ring shell, and the repair liquid flows out from the hydrolysis gap of the melon ring to achieve hemostasis, coagulation, and sterilization. The main components in the bandage are all biodegradable materials, which can be directly buried in the soil, and have high biodegradation rate and small environmental pollution. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of the biodegradable nanofiber medical bandage, which involves (S1) (i) preparing repair liquid by mixing caffeic acid and caffeic acid phenethyl ester and stirring in absolute ethanol, adding aminomethylbenzene acid and stirring, (ii) preparing modified graphene oxide by stirring and dissolving silane coupling agent in ethanol to obtain a solution (B), placing graphene oxide in deionized water, ultrasonically dispersing, adding a solution (B), continuously stirring, filtering and washing, (iii) synthesizing nano-functional microspheres by mixing zinc nitrate hexahydrate and melon ring, and stirring to obtain solution (C), placing the modified graphene oxide in ethylene glycol, stirring, dispersing, adding solution (C) for ultrasonic dispersion, adding sodium citrate to continuously the ultrasonic reaction, adjusting the pH value to obtain solution (D), placing the solution (D) in an autoclave, filtering, washing and vacuum drying to obtain powder (A), and placing the powder (A) in the repair liquid for ultrasonic dispersion, evaporating the excess repair liquid and drying, (S2) preparing nuclear layer spinning solution by placing porous starch in sodium lauryl sulfate solution and stirring to obtain material (A), stirring and mixing N,N-dimethylformamide, dibutyltin dilaurate, and triethylene diamine, adding a material (A), adding diphenylmethane diisocyanate, adding chloroform after stirring, ultrasonically dispersing, suction filtrating, washing and drying to obtain modified porous starch, placing the chitosan and alginic acid in the ethanol solution and stirring to dissolve, adding the modified porous starch, stirring the reaction, dripping the crosslinking agent and stirring, (S3) preparing a shell spinning solution by mixing gelatin and zein, adding nano-functional microspheres and long-chain molecules and stirring, and (S4) preparing bandage by stirring propylene glycol, hydroxysilicone oil, carboxysilicone oil, organosiloxane, lecithin, and ammonia to obtain a hydrophobic finishing agent, immersing the ordinary yarn in a hydrophobic finishing agent, freeze-drying and placing on an electrospinning receiving plate as a support layer for receiving nanofibers, using the coaxial electrostatic spinning process to form the core layer spinning solution and the shell layer spinning solution into nanofibers with a shell-core structure, collecting on the support layer to obtain a repair layer, drying and sterilizing.