• 专利标题:   Hot melt casting type nano-composite gel antibacterial agent comprises hot melt binder, nanoparticles, radiation sensitizer, pH regulator and emulsifying agent, where antibacterial agent is formed by radiation crosslinking reaction of hot-melt binder and antibacterial nanomaterial base material.
  • 专利号:   CN115137750-A
  • 发明人:   YANG X, FU L, WANG Z, WANG Y, YANG J, LIU D, RAO L, LI Y
  • 专利权人:   UNIV HUBEI SCI TECHNOLGY
  • 国际专利分类:   A61K033/42
  • 专利详细信息:   CN115137750-A 04 Oct 2022 A61K-033/42 202201 Chinese
  • 申请详细信息:   CN115137750-A CN10634786 07 Jun 2022
  • 优先权号:   CN10634786

▎ 摘  要

NOVELTY - A hot melt casting type nano-composite gel antibacterial agent comprises 70-80 %mass hot melt binder, 2-10 %mass nanoparticles, 1-4.0 %mass radiation sensitizer, 0.2-4.0 %mass pH regulator and 2.0-4.0 %mass emulsifying agent, where the antibacterial agent is an antibacterial material obtained by radiation crosslinking reaction of hot-melt binder and antibacterial nanomaterial base material. USE - As hot melt casting type nano-composite gel antibacterial agent. ADVANTAGE - The hot melt casting type nano-composite gel antibacterial agent is non-toxic, cheap, and not easy to decompose, and has low temperature melting property, strong heat resistance, and high bactericidal power. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a preparation method of the hot melt casting type nano-composite gel antibacterial agent comprising (S1) mixing 70-80% hot melt binder, 2-10% nanoparticles, 1-4.0% radiation sensitizer and 0.2-4.0% pH regulator, ultrasonically stirring to prepare a uniform dispersion system, putting the uniform dispersion system to an oil bath pan for 6-8 hours and completely dissolving the uniform dispersion system to a sol state, (S2) adding 2.0-4.0% emulsifying agent to the sample obtained in step (S1) to prepare a dispersion system, filling the dispersion system into a culture dish, leaving for defoaming, placing in a refrigerator for carrying out freezing-thawing cycle for 3-5 times and storing, (S3) placing the sample obtained in step (S2) under ionizing radiation generated by γ-rays or electron beam for radiation crosslinking reaction, where the selected electron beam energy is 1-5 MeV, the radiation dose is 5-60 kGy, and the dosage rate is 5-20 kGy/pass and (S4) soaking the sample in deionized water to remove the uncrosslinked monomer and finally the obtained product is the hydrogel antibacterial agent.