• 专利标题:   Graphene oxide-berberine complex used in preparation of antitumor medicine, comprises graphene oxide as carrier, where berberine is linked electrostatically to graphene oxide to obtain nano graphene oxide-berberine complex.
  • 专利号:   CN103861119-A, CN103861119-B
  • 发明人:   XU K, YU D, ZHOU J, RUAN P
  • 专利权人:   UNIV CHINA PHARM, UNIV CHINA PHARM
  • 国际专利分类:   A61K031/4375, A61K047/48, A61P001/00, A61P001/12, A61P031/04, A61P035/00, A61K047/52
  • 专利详细信息:   CN103861119-A 18 Jun 2014 A61K-047/48 201456 Pages: 5 Chinese
  • 申请详细信息:   CN103861119-A CN10116563 26 Mar 2014
  • 优先权号:   CN10116563

▎ 摘  要

NOVELTY - Graphene oxide-berberine complex comprises graphene oxide as carrier. Berberine is linked electrostatically to graphene oxide to obtain nano graphene oxide-berberine complex. USE - Graphene oxide-berberine complex used in preparation of antitumor medicine. ADVANTAGE - The graphene oxide-berberine complex improves oral absorption of berberine hydrochloride. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing graphene oxide-berberine complex, which involves: (A) mixing 5 % of dimethyl sulfoxide (0.1 mg/ml), graphene oxide (3ml) and aqueous solution of berberine (0.8mg/ml) and then shaking at 25 degrees C for 24 hours to obtain mixture; and (B) centrifuging the obtained mixture and then washing with deionized water to obtain the product.