▎ 摘　　要

NOVELTY - Edible antibacterial medicine packaging film comprises e.g. 15 pt. wt. graphene oxide, 8 pt. wt. beta-cyclodextrin, 25 pt. wt. modified chitin, 40 pt. wt. quaternized konjac glucomannan, 7 pt. wt. glycerol and 5 pt. wt. crosslinking agent. The preparation method of the edible antibacterial drug packaging film comprises (1) mixing chitosan and 2,2,6,6-tetramethylpiperidine-1-oxyl radical in a beaker in a mass ratio of 100:1, adding 50 times the mass of chitosan with a concentration of 0.05 mol/l phosphate buffer solution and 1.2 times the mass of chitosan with sodium chlorite to the beaker, stirring and mixing to obtain a chitosan mixed solution, mixing chitosan with a sodium hypochlorite solution with a mass fraction of 15% in a volume ratio of 25:1, stirring and reacting for 4 hours at a temperature of 60℃ and a rotation speed of 400 revolutions/minute. USE - The edible antibacterial medicine packaging film is useful in packaging bag for medicine packaging and solid raw material medicine. ADVANTAGE - The edible antibacterial drug packaging film has excellent mechanical properties and antibacterial properties; does not cause toxic harm to the human body after being accidentally eaten by the human body, and can remove excess oil in the human body. DETAILED DESCRIPTION - 15 pt. wt. graphene oxide, 8 pt. wt. beta-cyclodextrin, 25 pt. wt. modified chitin, 40 pt. wt. quaternized konjac glucomannan, 7 pt. wt. glycerol and 5 pt. wt. crosslinking agent. The preparation method of the edible antibacterial drug packaging film comprises (1) mixing chitosan and 2,2,6,6-tetramethylpiperidine-1-oxyl radical in a beaker in a mass ratio of 100:1, adding 50 times the mass of chitosan with a concentration of 0.05 mol/l phosphate buffer solution and 1.2 times the mass of chitosan with sodium chlorite to the beaker, stirring and mixing to obtain a chitosan mixed solution, mixing chitosan with a sodium hypochlorite solution with a mass fraction of 15% in a volume ratio of 25:1, stirring and reacting for 4 hours at a temperature of 60°C and a rotation speed of 400 revolutions/minute, repeatedly washing the slurry in the flask with deionized water until the pH of the slurry in the flask is adjusted to 7, centrifuging for 15 minutes under the condition of rotating speed of 8000 revolutions/minute to obtain the modified chitin mixture, and adjusting the pH of the modified chitin mixture to 11 with lye, performing ultrasonic treatment for 2 hours at a frequency of 50 kHz, centrifuging for 15 minutes at a rotational speed of 7000 revolutions/minute, concentrating rotary evaporation to remove moisture to obtain modified chitin, and mixing the modified chitin with 5% acetic acid in a mass ratio of 1:15 to obtain a modified chitin solution, and (2) mixing the graphene oxide dispersion and β-cyclodextrin in a flask in a mass ratio of 12:1, adding the modified chitin solution to the flask by 1 times the mass of the graphene oxide dispersion, performing ultrasonic mixing for 40 minutes under the condition of power of 50kHz, add a crosslinking agent with a mass of 0.08 times the mass of graphene oxide dispersion into the flask, stirring at a temperature of 90°C, reacting for 2 hours under the condition of a rotating speed of 400 revolutions/minute, filtering to obtain the additive blank, and drying the additive blank at a temperature of 80 ℃ for 4 hours to obtain the additive, and (3) mixing quaternized konjac glucomannan and water in a mixer at a mass ratio of 1:10, adding the additive of 1.2 times the mass of quaternized konjac glucose and glycerol with 0.175 times the mass of quaternized konjac glucose into the mixer, stirring and mixing for 40 minutes under the condition of pH 3, coating the film to obtain the edible antibacterial drug packaging film blank, drying the edible antibacterial drug packaging film blank to a constant weight at a temperature of 50°C, peeling off the film to obtain an edible antibacterial drug packaging film, where the preparation method of chitosan includes mixing sodium borohydride and sodium hydroxide solution with a mass fraction of 33% in a mass ratio of 1:85, adding chitin with a mass of 3.5 times sodium borohydride, stirring and reacting for 4 hours at a temperature of 90 ° C, filtering with suction to obtain a chitin blank, washing the chitosan blank with a mass fraction of 50% ethanol aqueous solution to neutrality, drying the washed chitosan blanks by blasting for 12 hours to obtain chitosan. The preparation method of the graphene oxide dispersion includes mixing graphene oxide and water in a mass ratio of 3:100, performing ultrasonic dispersion for 40 minutes under the condition of a frequency of 50kHz to obtain a graphene oxide dispersion liquid. The preparation of the quaternized konjac glucomannan includes mixing konjac glucomannan and isopropanol in a mass ratio of 1:12, and adding 2,3-epoxypropyltrimethylammonium chloride aqueous solution with 10 times the mass of konjac glucomannan, stirring and reacting to obtain a quaternized konjac glucomannan mixture, washing the quaternized konjac glucomannan mixture 6 times with 80% isopropanol solution, filtering under reduced pressure to obtain the quaternized konjac glucomannan blank, dialyzing the quaternized konjac glucomannan blank in deionized water for 48 hours, and then precipitating with acetone to obtain a quaternized konjac glucomannan mixture. The preparation method of 2,3-epoxypropyltrimethylammonium chloride aqueous solution includes mixing epichlorohydrin and water by volume ratio 1:2.5 to obtain an aqueous solution of epichlorohydrin, passing trimethylamine gas into the aqueous solution of epichlorohydrin, reacting with ice water for 30 minutes, reacting at room temperature for 3 hours to obtain a mixed solution of 2,3-epoxypropyltrimethylammonium chloride, where the mixed solution of 2,3-epoxypropyltrimethylammonium chloride and acetone in a mass ratio of 3:1, filtering to obtain 2,3-epoxypropyltrimethylammonium chloride, mixing 2,3-epoxypropyltrimethylammonium chloride and water in a mass ratio of 3:10 to obtain 2,3-epoxypropyltrimethylammonium chloride aqueous solution. The cross-linking agent in step (2) is obtained by mixing genipin and sodium ascorbate in a mass ratio of 1:2 to obtain a cross-linking agent.