▎ 摘　　要

NOVELTY - Nanopore sensor (100) comprises nanopore (12) set in support structure (14). The first fluidic reservoir including fluidic solution has first ionic concentration. The fluidic passage is set in fluidic connection between first fluidic reservoir and nanopore. The fluidic passage has fluidic passage cross-sectional extent, along portion of fluidic passage length, that is greater than diameter of nanopore and less than fluidic passage length. The fluidic passage has fluidic passage resistance, RFP, of 10% of nanopore resistance, RPore, and no more than about 10 times nanopore resistance, RPore. The second fluidic reservoir comprises fluidic solution having second ionic concentration. The nanopore is set in fluidic connection between second fluidic reservoir and fluidic passage. The electrical transduction element is set at fluidic passage and electrically connected to produce indication of electrical potential local to fluidic passage. USE - Nanopore sensor used for local electrical potential measurement. ADVANTAGE - The nanopore sensor has large scale integration capability, provides constant and reproducible physical aperture, enhances sensitivity, and minimizes signal attenuation. DESCRIPTION OF DRAWING(S) - The drawing shows schematic view of a nanopore sensor. 12Nanopore 14Support structure 100Nanopore sensor 102Cis reservoir 104Trans reservoir