• 专利标题:   Biodegradable sports contusion health care patch used for e.g. promoting blood circulation, comprises degradable backing layer, sodium polyacrylate adhesive layer coated on surface of degradable backing layer and substrate comprising nano bacterial cellulose powder, chitosan and sinomenine.
  • 专利号:   CN113499363-A
  • 发明人:   ZHANG Z, LIU Y, ZENG X, SUN J, CAO L, LIU X, HUANG L
  • 专利权人:   HAINAN AISI ZHUOPU TECHNOLOGY CO LTD
  • 国际专利分类:   A61K036/258, A61K031/485, A61K031/365, A61K031/351, A61P029/00, A61P019/00, A61K047/44, A61K047/42, A61K047/38, A61K047/36, A61K047/34, A61K047/10, A61K047/32, A61K009/70, A61K036/54
  • 专利详细信息:   CN113499363-A 15 Oct 2021 A61K-036/54 202101 Chinese
  • 申请详细信息:   CN113499363-A CN10756773 05 Jul 2021
  • 优先权号:   CN10756773

▎ 摘  要

NOVELTY - Biodegradable sports contusion health care patch comprises a degradable backing layer, a sodium polyacrylate adhesive layer coated on the surface of the degradable backing layer, and a substrate coated on the surface of the sodium polyacrylate adhesive layer. The substrate comprises a sustained-release gel component comprising 10-40% nano bacterial cellulose powder, 5-10% chitosan, 1.5-7.5% sinomenine, 2.5-8.0% panax notoginseng saponins, 10-15% gel, 3-10% ternary composite penetration enhancer eucalyptus oil, 0.75-1.5% ostrich oil and 2-5% N-methyl-2-pyrrolidone; an immediate-release component comprising 1.25-7.5% costus lactone, 1.25-7.5% safflower yellow pigment and 2.25-7.5% cassia twig essential oil; 0 .3-1.9% composite crosslinking agent; 10-20% humectant and remaining is purified water. USE - The health care patch is useful for promoting blood circulation, relieving muscle soreness and providing analgesia and anti-inflammatory effects. ADVANTAGE - The health care patch exerts a long-term analgesic effect. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing the health care patch involving (1) preparing nano bacterial cellulose powder by adding 50 -75% bacterial cellulose, 5 -10% sodium hydroxide and 5 -15% urea to purified water, stirring at 30-80degrees Celsius and 100-200 rpm/min, or using ultrasonic oscillation or microwave technology, where the ultrasonic power is 300-400W, microwave power is 100-300W, temperature is 30-80degrees Celsius and reaction time of ultrasonic or microwave operation is 30-90 minutes, dissolving the bacterial cellulose completely and removing bubbles, passing through 80-100 mesh sieve for product separation; performing 3 freeze-thaw cycles, freezing at -20degrees Celsius to 36degrees Celsius for 12-24hours each time, and thawing at room temperature for 6-10 hours, after the first two freeze-thaw cycles are thawed, washing the bacterial cellulose membrane material with purified water to pH 7, freeze-drying, adopting the pre-freeze temperature of -55degrees Celsius to 65degrees Celsius and pre-freezing time of 6-10 hours, partition temperature of 45-60degrees Celsius, the drying time of 24-48 hours, after the third freeze-drying, the nano-bacterial cellulose powder is obtained, (2) preparing a sustained-release gel component by adding 1.5 -7.5% sinomenine and 2.5-8% panax notoginseng saponins to 10-15% gel, adding 3 -10% ternary compound penetration enhancer eucalyptus oil, 0.75-1.5% ostrich oil and 2 -5% N-methyl-2-pyrrolidone, heating at 40-60degrees Celsius and carrying out heat preservation and stirring for 0.5-1.5 hours to prepare the sustained-release gel component, (3) preparing the substrate by putting costus lactone, safflower yellow pigment and cassia twig essential oil, composite crosslinking agent and humectant into the sustained-release gel component, heating at 40-60degrees Celsius, performing heat preservation and stirring for 0.5-1.5 hours, adding 10-40% nano bacterial cellulose powder, 5 -10% chitosan and purified water, heating at 40-70degrees Celsius and stirring for 1-2 hours to obtain the substrate and (4) firstly coating a degradable backing surface with a sodium polyacrylate adhesive layer, and coating the substrate on the surface of the sodium polyacrylate adhesive layer to obtain the product.