• 专利标题:   Detection of tetrahydrocannabinol used for e.g. medical applications, involves contacting sample with graphene layer functionalized with antibody, applying time-varying electric field, and monitoring electrical property of graphene layer.
  • 专利号:   WO2020210743-A1
  • 发明人:   FOTOUHI M, ABEDI M, GREENFIELD E A, MOLLAAGHABABA R, TASLIM M E
  • 专利权人:   RITE TASTE LLC
  • 国际专利分类:   A61B005/00, G01N027/04, G01N033/487
  • 专利详细信息:   WO2020210743-A1 15 Oct 2020 A61B-005/00 202088 Pages: 36 English
  • 申请详细信息:   WO2020210743-A1 WOUS027827 10 Apr 2020
  • 优先权号:   US832264P, US422743

▎ 摘  要

NOVELTY - Detection of tetrahydrocannabinol (THC) in a sample involves contacting the sample with a graphene layer (1004) functionalized with an antibody exhibiting specific binding to THC, applying a time-varying electric field to antibody-functionalized graphene layer, monitoring at least one electrical property of graphene layer with respect to interaction with sample, and detecting presence of THC in the sample by detecting a change in electrical property indicative of interaction of THC with anti-body functionalized graphene layer. USE - Detection of tetrahydrocannabinol e.g. ( Delta )-9-tetrahydrocannabinol, 11-carboxy-tetrahydrocannabinol and 11-hydroxy-tetrahydrocannabinol in sample e.g. food sample and biological sample such as blood, saliva and urine sample (all claimed) used for medical and recreational applications. ADVANTAGE - The method effectively enables detection of a change in the resistance of the underlying graphene layer with respect to the interaction of the antibodies with THC present in the sample. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for system for detecting THC in sample. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of the sensor system. Sensor (1000) Substrate (1002) Silicon oxide layer (1003) Graphene layer (1004) Reference electrode (3001)