▎ 摘　　要

NOVELTY - A polyethylene glycol modified graphene oxide is prepared by reacting a carbon-containing solid with a reactant in a solvent to form a graphene oxide precursor which is dispersed along with a polyethylene glycol substance and a dehydrating agent, in an aprotic solvent. The reaction is catalyzed by a catalyst. The reactant used is sulfur trioxide, chlorosulfonic acid, sulfur dioxide, sodium sulfite, sulfurous acid, peroxydisulfuric acid, ammonium persulfate and/or concentrated sulfuric acid. The solvent used is aqueous ammonia, toluene, xylene, anisole, concentrated sulfuric acid, 30 wt.% hydrogen peroxide solution, deionized water, methanol, ethanol, propanol, dichloromethane, N-dimethylformamide, N-dimethylacetamide, acetone, butanone, diethyl ether and/or tetrahydrofuran. The aprotic solvent used is dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide, acetone, butanone, acetonitrile and/or tetrahydrofuran. USE - The polyethylene glycol-modified graphene oxide is used for adsorption of low abundance protein (claimed) in complex biological samples. The graphene oxide is also used in sample pretreatment in biology and medicine applications. ADVANTAGE - The polyethylene glycol modified graphene oxide prepared, has low agglomeration and improved dispersibility. The method is a stable and highly sensitive process which enables to prepare graphene oxide which has good performance in acid-base environments of most biological samples. The graphene oxide suitable for extracting and separating low-abundance proteins in complex biological samples, has efficiency in removing protein-pollutants in the biological samples. DETAILED DESCRIPTION - A polyethylene glycol modified graphene oxide is prepared by reacting a carbon-containing solid (A) with a reactant in a solvent to form a graphene oxide precursor which is dispersed along with a polyethylene glycol substance and a dehydrating agent, in an aprotic solvent, the reaction is catalyzed by a catalyst. The reactant used is sulfur trioxide, chlorosulfonic acid, sulfur dioxide, sodium sulfite, sulfurous acid, peroxydisulfuric acid, ammonium persulfate and/or concentrated sulfuric acid. The solvent used is aqueous ammonia, toluene, xylene, anisole, concentrated sulfuric acid, 30 wt.% hydrogen peroxide solution, deionized water, methanol, ethanol, propanol, dichloromethane, N-dimethylformamide, N-dimethylacetamide, acetone, butanone, diethyl ether and/or tetrahydrofuran. The aprotic solvent used is dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide, acetone, butanone, acetonitrile and/or tetrahydrofuran. The catalyst used is cuprous bromide, cuprous chloride, cupric bromide, zinc chloride, sodium chloride, ferrous chloride, ferric chloride, aluminum chloride, boron trifluoride diethyl ether, boron trichloride, cobalt chloride, 4-dimethylaminopyridine, triethylamine, tetramethylethylenediamine and/or pentamethyl diethylenetriamine. An INDEPENDENT CLAIM is included for the production of polyethylene glycol-modified graphene oxide. DESCRIPTION OF DRAWING(S) - The drawing shows plot of sample A, sample B and sample C of polyethylene glycol-modified graphene oxide.