▎ 摘　　要

NOVELTY - Molecular sensor device comprises: an insulator thin-film disposed directly adjacent to a back-gate substrate; at least one positive electrode disposed directly adjacent to the insulator thin film, opposite to the back-gate substrate; at least one negative electrode disposed directly adjacent to the insulator thin film, opposite to the back-gate substrate; clean graphene disposed between, and in electrical communication with, the positive and negative electrodes, where the clean graphene is functionalized with a nucleic acid. USE - The molecular sensor device is useful for detecting compounds (claimed). ADVANTAGE - The molecular sensor device: has high sensitivity to a large variety of compounds; and utilizing single-stranded DNA, which provides sequence-dependent chemical recognition capability, thus enables the required number of chemically distinct sensor responses; and improves the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) detecting a compound, comprising contacting the single-stranded DNA functionalized clean graphene sensor device with a medium, monitoring conductance of the single-stranded DNA functionalized clean graphene to determine the presence, absence and/or concentration of molecules, and correlating a change in conductance to the presence, absence and/or concentration of molecules; and (2) a system comprising many molecular sensor devices.