▎ 摘　　要

NOVELTY - Core-shell nanofiber, comprises an inner core, and an outer shell, where the inner core comprises a hydrophilic polymer and an active ingredient, and the outer shell comprises a hydrophobic polymer and plasmonic nanoparticles. USE - The nanofiber is useful for delivering the active ingredient to cells on-demand and laser mediated intracellular delivery (all claimed) to treat cancers, cell-based therapies, and tissue engineering. No biological data given. ADVANTAGE - The nanofiber utilizes: plasmonic nanoparticles that allow laser mediated optoporation to facilitate drug delivery to neurons cultured on nanofiber mat; and plasmonic nature of gold nanoparticles that generate high electric field on laser exposure, resulting in localized temperature increase and generation of transient bubbles. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) preparing the core-shell nanofiber, comprising (a) dissolving hydrophilic polymer in distilled water and mixing it with an active ingredient to make a first mixture, (b) dissolving hydrophobic polymer in a polar solvent and mixing it with plasmonic nanoparticles to make a second mixture, (c) adding first mixture in syringe 1 and second mixture in syringe 2, and (d) electrospinning the mixtures; and (2) delivering the active ingredient to cells on-demand, comprising administering the nanofiber to a subject, and exposing the treatment site to laser for intracellular release of the active ingredient.