• 专利标题:   Catalyst used for synthesizing quinazoline compound comprises iron oxide doped with copper iodide loaded in graphene oxide.
  • 专利号:   CN105289663-A
  • 发明人:   FAN L, KONG L
  • 专利权人:   UNIV TONGJI
  • 国际专利分类:   B01J027/122, C07D239/90, C07D239/91
  • 专利详细信息:   CN105289663-A 03 Feb 2016 B01J-027/122 201642 Pages: 18 English
  • 申请详细信息:   CN105289663-A CN10697690 23 Oct 2015
  • 优先权号:   CN10697690

▎ 摘  要

NOVELTY - Catalyst comprises iron oxide doped with copper iodide loaded in graphene oxide. The loading weight of copper ion is 10-11 wt.%. USE - Catalyst used for synthesizing quinazoline compound (claimed). ADVANTAGE - The catalyst is simple and can be recycled without losing high efficiency. It has high activity, and high recovery rate. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) preparation of catalyst comprising adding graphene oxide powder in 2-pyrrolidinone, and sonicating under nitrogen atmosphere for 2-4 hours to get mixture; heating mixture, mechanical stirring, adding dropwise ferric acetylacetonate solution, and stirring under reflux to get black precipitate; magnetic recovering black precipitates, washing and drying; and adding copper iodide in anhydrous ethanol under nitrogen atmosphere, stirring under reflux, recovering solid black, washing, and drying; and (2) synthesis of quinazolinone compound comprising mixing catalyst, amino acids, cesium carbonate, and o-halo benzamide glycol/dimethyl sulfoxide at 110-130 degrees C under reflux for 5-7 hours; recovering magnetic black solids after reacting, washing and drying to recover catalyst; and magnetic recovering remaining mixture in second step with ethyl acetate and water at ratio of 1:1, extracting with extractant, and separating organic phase quinazolinone compound by column chromatography.