▎ 摘　　要

NOVELTY - Graphene loading combined treatment for cancer comprises (i) connecting hydrophobic-hydrophobic interaction between hydrophobic surface of graphene and fat-soluble molecules, coating graphene on nanoparticles to form core-shell structure and embedding graphene in polymer to form complex structure, (ii) loading graphene complex structure with anti-cancer medicine and apoptosis peptides, coating bovine serum albumin, stirring, adding 2-methylimidazole powder, centrifuging and incubating, (iii) washing medicine-loaded complex and drying, (iv) characterizing carbon quantum dots and physical and chemical properties of the medicine-loaded complex by e.g. ultraviolet light irradiation, fluorescence absorption radiation spectroscopy, (v) dispersing in water and using adriamycin to treat or alleviate cancer of tissue or organ, and (vi) designing tumor treatment platform using graphene-based materials and using graphene oxygen-containing functional groups to react and connect. USE - The method is useful for graphene loading combined treatment for cancer. ADVANTAGE - The method: utilizes graphene-based material which has good load and transport capacity; enhances blood circulation and improves oxygen status in tumor. DETAILED DESCRIPTION - Graphene loading combined treatment for cancer comprises (i) connecting hydrophobic-hydrophobic interaction between hydrophobic surface of graphene and fat-soluble molecules, connecting hydrophilic molecules at the edges through electrostatic interaction phases or hydrogen bonds, coating graphene on the surface of nanoparticles to form a core-shell structure and embedding graphene in the polymer to form a complex structure using pi - pi bonds or hydrogen bonds, (ii) loading graphene complex structure with anti-cancer medicine and apoptosis peptides, coating bovine serum albumin on the outermost layer of graphene complex structure, mixing and stirring for 5 minutes, adding 2-methylimidazole powder in a drop wise manner, stirring for 15 minutes, collecting by centrifugation and incubating in a shaker under dark for 24 hours to obtain a medicine-loaded complex, (iii) washing medicine-loaded complex thrice using a mixture of water and methanol and quickly drying at low temperature under vacuum, (iv) characterizing carbon quantum dots and physical and chemical properties of the medicine-loaded complex by ultraviolet light irradiation, fluorescence absorption radiation spectroscopy, ultraviolet absorption spectroscopy, contact angle detection, zeta potential detection, fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and X-ray powder diffraction (XRD), (v) uniformly dispersing medicine-carrying complex with qualified physical and chemical properties in water under ultrasonic conditions to prepare intravenous injection preparation and using adriamycin alone or in combination to treat or alleviate cancer of a tissue or organ, including leukemia and solid tumors and (vi) designing tumor treatment platform using graphene-based materials which is affected by different factors e.g. light, heat, electricity, magnetism and acidity for auxiliary treatment, where the operation principle is to covalently insert organic molecules, nanoparticles or polymers into the graphene framework and using graphene oxygen-containing functional groups to react and connect which will be affected by various stimuli to assist therapy.