▎ 摘　　要

NOVELTY - The system has a skin-wearable printed sensor coupled to electronics and provided with stretchable graphene sensors, two electrodes, a conductive flexible film and an elastomeric substrate. The electrodes comprise a graphene layer in contact with a polyimide layer, where the polyimide layer contacts with the elastometric substrate. The flexible film connects the sensor with the electronics, where the electronics comprise an antenna, a , a microprocessor, an acquisition electronics (114) and a battery. A sensor (122) is selected from an electrical sensor, an impedance sensor and an infrared sensor. USE - System for monitoring electrophysiological parameter of a subject i.e. animal model e.g. craniofacial VML model such as mice, rat and zebrafish, by using a wearable device (all claimed). ADVANTAGE - The system provides real-time continuous monitoring of electro-physiological parameters of the subject in a non-invasive manner, allows researchers to extrapolate results of the animal model studies to understand human physiology and disease and provides invaluable information in pursuit of scientific and medical knowledge and development of drugs and treatments in preclinical investigations of research and development. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: an animal model a method for monitoring electrophysiological parameter of a subject a method for identifying therapeutic agent a wearable device a craniofacial VML model a method for monitoring a VML. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic block diagram of a system for facilitating real-time continuous monitoring of an animal model. 102Animal model 114Acquisition electronics 116Controller 122Sensor 130Network interface