• 专利标题:   Immobilizing nucleic acid structures on graphene, involves contacting nucleic acid structure having molecule-modified oligonucleotide with graphene layer.
  • 专利号:   EP3699142-A1
  • 发明人:   KAMINSKA I, TINNEFELD P
  • 专利权人:   INST CHEM FIZYCZNEJ POLSKIEJ AKAD NAUK, UNIV MUENCHEN MAXIMILIANS LUDWIG
  • 国际专利分类:   B82Y015/00, C01B032/184, C01B032/194, C12Q001/68, G01N027/414
  • 专利详细信息:   EP3699142-A1 26 Aug 2020 C01B-032/184 202073 Pages: 20 English
  • 申请详细信息:   EP3699142-A1 EP461514 20 Feb 2019
  • 优先权号:   EP461514

▎ 摘  要

NOVELTY - Method of immobilizing nucleic acid structures on graphene involves (i) providing at least one type of nucleic acid structure having at least one type of molecule modified oligonucleotide, where the molecule is able to attach to graphene through pi -interactions, and (ii) contacting the nucleic acid structure having at least one type of molecule-modified oligonucleotide with graphene layer at temperature of 0-100 degrees C, so that immobilization of nucleic acid structures on the graphene is achieved. USE - The method is useful for immobilizing nucleic acid structures on graphene or modifying graphene by immobilizing nucleic acid structures such as DNA origami structures in biosensing and energy conversion and photovoltaics and optoelectronics (all claimed). DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) graphene modified by immobilization of nucleic acid structures comprising at least one type of nucleic acid structure and graphene layer, where the nucleic acid structure is immobilized on the graphene layer through molecule-modified oligonucleotides, where the molecule is able to attach to graphene through pi -interactions, where the molecule-modified oligonucleotides are complementary for Watson-Crick pairing to oligonucleotides comprised in nucleic acid structures; and (2) graphene modified by immobilization of DNA origami structures comprising at least one type of DNA origami structure and graphene layer, where the DNA origami structure is immobilized on the graphene layer through pyrene-modified oligonucleotides which are complementary for Watson-Crick pairing to oligonucleotides protruding from the DNA origami structure and/or built into DNA origami structure.