• 专利标题:   Bone-targeted drug-loading system comprises bone morphogenetic protein 2 modified polysaccharide-graphene quantum dot gel complex.
  • 专利号:   CN108939085-A
  • 发明人:   GAO J, HU J, WANG D, ZHANG X
  • 专利权人:   CHANGZHOU TCM HOSPITAL
  • 国际专利分类:   A61K047/42, A61K047/04, A61K047/36, A61K047/26, A61K047/40, A61K009/06, A61P019/10
  • 专利详细信息:   CN108939085-A 07 Dec 2018 A61K-047/42 201917 Pages: 86 Chinese
  • 申请详细信息:   CN108939085-A CN10915563 13 Aug 2018
  • 优先权号:   CN10915563

▎ 摘  要

NOVELTY - Bone-targeted drug-loading system comprises bone morphogenetic protein 2 (BMP-2) modified polysaccharide-graphene quantum dot gel complex, where the BMP-2 is a guide or target, the polysaccharide-graphene quantum dot gel is a drug carrier, and the BMP-2 is attached to the surface of the polysaccharide-graphene quantum dot gel. USE - As bone-targeted drug-loading system. ADVANTAGE - The bone-targeted drug-loading system is an excellent drug carrier having bone targeting. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for preparing the bone-targeted drug-loading system involves (a) preparing polysaccharide-graphene quantum dot gel, (b) constructing BMP-2 plasmid, and (c) preparing BMP-2 modified polysaccharide-graphene quantum dot gel complex by mixing polysaccharide-graphene quantum dot gel and BMP-2 plasmid uniformly, centrifuging the mixture, placing the mixture in a water bath, preheating the mixture using a water bath at 40-60 degrees C for 10-30 minutes, vortexing the mixture, placing the mixture at room temperature to obtain a polysaccharide-graphene quantum dot-BMP-2 CDNA, centrifuging the mixture, discarding supernatant, rinsing the precipitate, and freeze-drying the precipitate to obtain BMP-2 modified chitosan-graphene quantum dot gel.