▎ 摘　　要

NOVELTY - Device comprises a strip (11), biosensor, processor, and communication unit, where the strip receives test sample selected from saliva, urine or sweat and propagates the sample to flow through the strip where the test sample encounters the biosensor provided in conjunction with the strip, which biosensor detects the one or more biomarkers present in the test sample of saliva, urine or sweat. The processor is a high-end micro-controller and it gives input signal and power to the biosensor to runs and function the whole detection device. The communication unit is an interface between a user detection device and the processor providing information and test results or readings to be communicated to the user. The biosensor of the device detects and quantify the saliva, urine or sweat biomarkers selected from cathepsin D, K, L, S and other protein markers or combination, involved in cancer, and metabolic diseases. USE - Device for detection and prognosis of chronic disease. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a method for detection and prognosis of chronic disease, which involves using a portable non-invasive detection device, which detection device comprises a strip; biosensor; processor; and communication unit, where the strip receives test sample selected from saliva, urine or sweat and propagates the sample to flow through the strip where the test sample encounters the biosensor provided in conjunction with the strip, which biosensor detects the one or more biomarkers present in the test sample of saliva, urine or sweat; where, the processor is a high-end micro-controller and it gives input signal and power to the biosensor to runs and function the device; where the communication unit is an interface between a user detection device and the processor providing information and test results or readings to be communicated to the user; where the biosensor of the device detects and quantify the saliva, urine or sweat biomarkers selected from cathepsin D, K, L, S and other protein markers or combination, involved in cancer, and metabolic diseases; and (2) a method to detect human saliva, urine and sweat biomarkers including cathepsins (D, K, L, S, etc) along with other protein biomarkers indicating in cancer and chronic metabolic diseases including diabetes, neurological and cardiovascular comprising a nano biosensor or quartz crystal piezo electric biosensor, where biosensor comprises a type of biosensor selected from Type I, Type II, Type III, Type IV and Type V biosensor or combination. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of device. Strip (11) Plastic cap (12) Chip (13) Display unit (14)