▎ 摘　　要

NOVELTY - Non-covalent bond and covalent bond double coupling cross-linked injectable moldable printable gelatin particle or core-shell gelatin particle hydrogel material is claimed. The gelatin particles or core-shell gelatin particles in the hydrogel material are used as basic structural unit. In the gelatin particle hydrogel material, a continuous and porous particle network is formed by reversible non-covalent cross-linking and covalent bond cross-linking between gelatin particles; the gelatin particles can reversibly self-assemble under the action of non-covalent bonds to form continuous porous particle network and achieves injectable, printable, shapeable, and self-repairing properties; the high-strength gelatin particle hydrogel is formed by initiating covalent bond cross-linking; and the size range of the gelatin particles is 2050 mu m. USE - The hydrogel material is useful as post-operative wound closure-skin repair materials or medicines; as material or medicine for preparation of postoperative wound closure-oral ulcers; as preparation of tissue fluid leakage sealing-intestinal leakage sealing material or medicine; as preparation of interstitial fluid leakage sealing-surgical suture material or medicine; as preparation of hemostatic material-liver hemostatic material or medicine; as hemostatic material or medicine for preparation of hemostatic material-bone section hemostatic material; as preparation of hemostatic materials-arterial hemostatic materials or drugs; as preparation of hemostatic material-cardiac hemostatic material or medicine; as support material for tissue engineering-cartilage repair material or medicine; as scaffold material for tissue engineering-bone repair material or medicine; as material or medicine for preparation of tissue engineering scaffold material-bone/cartilage composite defect repair material (claimed). DETAILED DESCRIPTION - Non-covalent bond and covalent bond double coupling cross-linked injectable moldable printable gelatin particle or core-shell gelatin particle hydrogel material is claimed. The gelatin particles or core-shell gelatin particles in the hydrogel material are used as basic structural unit. In the gelatin particle hydrogel material, a continuous and porous particle network is formed by reversible non-covalent cross-linking and covalent bond cross-linking between gelatin particles; the gelatin particles can reversibly self-assemble under the action of non-covalent bonds to form continuous porous particle network and achieves injectable, printable, shapeable, and self-repairing properties; and the high-strength gelatin particle hydrogel is formed by initiating covalent bond cross-linking; the size range of the gelatin particles is 2050 mu m, and the volume fraction of the gelatin particles in the gelatin particle hydrogel material is 2-100 v/v%; the degree of substitution of the covalent cross-linking groups on the gelatin polymer chain in the gelatin particles is 5-80%; the pore size of the continuous porous particle network is 0.1-100 mu m, and the gel network is formed by connecting particles through polymer chains; and the compressive elastic modulus of the obtained granular hydrogel is 0.5-500 kPa. In the core-shell structure particle hydrogel material, a continuous, porous network of particles is formed by reversible non-covalent bonds and covalent bonds between particles; core-shell structure gelatin particles can reversibly self-assemble under the action of non-covalent bonds to form a continuous porous particle network, and achieves injectable, printable, and moldable properties; the high-strength particle hydrogel is prepared by initiating the cross-linking of covalent bonds on the particle surface, enhancing the curing; the size of the shell layer particles of the core-shell structure particles is 50-50 mu m, and the size of the core layer particles is 10 nm to 1 mu m; the volume fraction of the total volume occupied by the core-shell structure particles in the particulate hydrogel material is 2-100 v/v%; the pore size of the obtained continuous porous particle network is 0.1-100 mu m; and the elastic modulus of the obtained granular hydrogel is 10-1000 kPa. INDEPENDENT CLAIMS are also included for: (1) preparing the hydrogel material; and (2) fast hemostatic sealing agent obtained by freeze-drying the gelatin particle suspension, the gelatin particle powder is uniformly blended with the chemical crosslinking agent or photocrosslinking agent powder, and then sprayed directly on the wound with blood defect, the powder fully absorbs the exuded blood, it is directly left to stand or through light-induced polymerization to achieve covalent cross-linking between the gelatin particles when the gelatin particle powder is not used, or the gelatin particle powder containing click chemistry cross-linking is blended, it is sprayed directly onto the wound with blood defect, the powder has fully absorbed and exuded blood, allowed it to stand directly to realize the covalent cross-linking between the gelatin particles, ands the particles form a stable bond with the tissue after crosslinking. R, R1 = H, halo, hydroxy, thio, amino, nitro, cyano, aldehyde group, ketone group, ester group, phosphonic acid group, phosphonate group, sulfonic acid group, sulfonate group, sulfone group, sulfoxide group, aryl group or alkyl group.