• 专利标题:   Nano graphene oxide/ultrasmall superparamagnetic iron oxide tumor diagnosis and treatment agent carrier used as carrier to load the anti-tumor medicine such as adriamycin in treatment agent as injection or oral preparation.
  • 专利号:   CN114159558-A
  • 发明人:   PAN M, QIN Q, WEI L, LU T, LI X
  • 专利权人:   UNIV GUANGXI MEDICAL
  • 国际专利分类:   A61K031/704, A61K041/00, A61K047/60, A61K047/61, A61K049/12, A61P035/00
  • 专利详细信息:   CN114159558-A 11 Mar 2022 A61K-041/00 202248 Chinese
  • 申请详细信息:   CN114159558-A CN10944845 10 Sep 2020
  • 优先权号:   CN10944845

▎ 摘  要

NOVELTY - Nano graphene oxide (NGO)/ultrasmall superparamagnetic iron oxide (USPIO) tumor diagnosis and treatment agent carrier modified by hyaluronic acid, is HPGOU, and has HA-PF68-NGO-USPIO structure. USE - Nano graphene oxide/ultrasmall superparamagnetic iron oxide tumor diagnosis and treatment agent carrier used as carrier to load the anti-tumor medicine such as adriamycin in treatment agent as injection or oral preparation, for diagnosis and treatment of SMMC-7721, HepG-2 and HL-7702 (all claimed). ADVANTAGE - The treatment agent carrier can ensure integrated diagnosis and treatment of tumor, reducing time of the medicine to the tumor,improving effective treatment amount, overcoming the deficiency of traditional chemotherapy medicine targeting, whole body toxicity is large, and tumor multi-drug resistance, which is a big breakthrough and important innovation of the existing single functional medicine. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing the NGO/USPIO tumour diagnosis and treatment agent carrier, which involves loading the USPIO on NGO drug-loading system by the coprecipitation method, then using the carboxyl respectively surface of the NGO for condensing the PF68 and hydroxyl on the HA to obtain the final product HPGOU.