• 专利标题:   Electrically-conductive scaffold for guiding differentiation and outgrowth of neural cells in peripheral nerve damage or in large-volume spinal cord injury in conjunction with electrical stimulation, comprises biomimetic matrix.
  • 专利号:   WO2022032203-A1
  • 发明人:   WANG H, WANG J
  • 专利权人:   STEVENS INST TECHNOLOGY
  • 国际专利分类:   A61B005/00, A61M031/00, A61N001/05, A61N001/20
  • 专利详细信息:   WO2022032203-A1 10 Feb 2022 202218 Pages: 91 English
  • 申请详细信息:   WO2022032203-A1 WOUS045117 06 Aug 2021
  • 优先权号:   US063158P

▎ 摘  要

NOVELTY - The scaffold has a biomimetic matrix includes an electrically conductive pattern of reduced graphene oxide. The scaffold is arranged in the forms of foams, sponges, fibers, meshes, membranes, spheres, hydrogels, and three-dimensional printed constructs, and is configured for use as a nerve conduit, to deliver biomolecules, to operate as a biosensor, and to provide electrical stimulation for treatment of large-volume spinal cord injury. The pattern of graphene oxide is adapted to regulate neural cell differentiation and neuritis outgrowth. The step of reducing said graphene oxide solution into pattern of graphene oxide. The step of applying a cationic polyelectrolyte. The cationic polyelectrolyte comprises branched polyethylenimine. USE - Electrically conductive scaffold For guiding differentiation and outgrowth of neural cells in peripheral nerve damage or in large-volume spinal cord injury in conjunction with electrical stimulation, and used in tissue engineering and regenerative medicine application. ADVANTAGE - The method enables the fabrication of conductive scaffolds with high conductivity and flexibility for any arbitrary configurations. The scaffolds require minimal graphene oxide for fabrication and are suited to mass production, with potential for automation. The controllable degradation can be varied depending on the substrate scaffold, and the inventive scaffolds have good handling capacity (i.e., flexible and stretchable). DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for making an electrically-conductive scaffold. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic diagram of a system for making scaffold.