• 专利标题:   Preparing hyperbranched polyglycidyl ether hydrogel dressing useful for preparation of trauma repairing medicine, comprises dissolving oxidized hyperbranched polyglycidyl ether in phosphate buffered saline solution, and mixing with chitosan composite solution.
  • 专利号:   CN114652889-A, CN114652889-B
  • 发明人:   TENG M, ZHANG P, LIU X, LIU Y, LUO X
  • 专利权人:   UNIV SHAANXI SCI TECHNOLOGY
  • 国际专利分类:   A61L026/00, C08G083/00
  • 专利详细信息:   CN114652889-A 24 Jun 2022 A61L-026/00 202280 Chinese
  • 申请详细信息:   CN114652889-A CN10291574 23 Mar 2022
  • 优先权号:   CN10291574

▎ 摘  要

NOVELTY - Preparing hyperbranched polyglycidyl ether hydrogel dressing comprises dissolving oxidized hyperbranched polyglycidyl ether in phosphate buffered saline solution, and mixing with chitosan composite solution at 20-40℃ to obtain final product. The mass ratio of oxidized hyperbranched polyglycidyl ether to chitosan in the solution is 1:0.5-1:1.5. The oxidized hyperbranched polyglycidyl ether is (I). USE - The hyperbranched polyglycidyl ether hydrogel dressing is useful for preparation of trauma repairing medicine (claimed). ADVANTAGE - The hyperbranched polyglycidyl ether hydrogel dressing: has rapid gelation time, self-repairing property, electrical stimulation responsiveness, excellent antibacterial performance against Gram-positive bacteria and Gram-negative bacteria, excellent biocompatibility, excellent effects on trauma repairing drugs and/or bandages, hemostatic, moisturizing and bacteriostatic effects on trauma; and can synergize with electrical stimulation to promote trauma repairing, and can detect the movement of human active parts. DETAILED DESCRIPTION - Preparing hyperbranched polyglycidyl ether hydrogel dressing comprises dissolving oxidized hyperbranched polyglycidyl ether in phosphate buffered saline solution, and mixing with chitosan composite solution at 20-40℃ to obtain final product. The mass ratio of oxidized hyperbranched polyglycidyl ether to chitosan in the solution is 1:0.5-1:1.5. The oxidized hyperbranched polyglycidyl ether is of formula (I). An INDEPENDENT CLAIM is also included for hydrogel dressing prepared by above method; the hydrogel dressing has a gel time of 42-45 second.