• 专利标题:   Medicine delivery system used to monitor medicine delivery and/or fluorescence/magnetic resonance imaging double-peak cell imaging, comprises magnetic nanoparticles used as core layer, and uses silicon dioxide modified by graphene quantum dots as shell layer, where dots are loaded with adriamycin.
  • 专利号:   CN114848846-A
  • 发明人:   FENG G, TENG Y
  • 专利权人:   SHENZHEN SURGSCIENCE MEDICAL TECHNOLOGY
  • 国际专利分类:   A61K031/704, A61K041/00, A61K047/52, A61K047/54, A61K047/69, A61K049/00, A61K049/08, A61K049/10, A61K049/18, A61P035/00, G01N021/64
  • 专利详细信息:   CN114848846-A 05 Aug 2022 A61K-047/69 202281 Chinese
  • 申请详细信息:   CN114848846-A CN10585525 26 May 2022
  • 优先权号:   CN10585525

▎ 摘  要

NOVELTY - Medicine delivery system comprises magnetic nanoparticles used as core layer, and uses silicon dioxide modified by graphene quantum dots as shell layer, and the graphene quantum dots are loaded with adriamycin. USE - The medicine delivery system or FRET model is useful in monitoring medicine delivery and/or fluorescence/magnetic resonance imaging double-peak cell imaging (claimed), and diagnosing and treating cancer. ADVANTAGE - The system: utilizes GQDs as both medicine carriers and donors in FRET model, and DOX as anticancer medicine and acceptor in FRET model; carries out efficient medicine loading and controlled release by FRET model; tracks the targeted tumor as a biomarker; realizes the monitoring and delivery of the medicine; and improves the diagnostic accuracy. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: a forster resonance energy transfer (FRET) model, comprising medicine delivery system, preferably, the graphene quantum dots are used as medicine carriers and/or donors in the FRET model, preferably, the adriamycin is used as an anticancer medicine and/or receptor in the FRET model; and preparing the medicine delivery system, comprising (i) modifying magnetic nanoparticles by emulsion polymerization method to obtain magnetic nanoparticles doped with silicon dioxide, (ii) subjecting magnetic nanoparticles doped with silicon dioxide to an amination reaction, and then reacting with graphene quantum dots to obtain graphene quantum dots-magnetic nanoparticles doped with silica, and (iii) mixing graphene quantum dots-magnetic nanoparticles doped with silicon dioxide with adriamycin to obtain doxorubicin/graphene quantum dots-magnetic nanoparticles doped with silicon dioxide.