▎ 摘　　要

NOVELTY - A photoelectrochemical sensor comprises electrode, a graphene-nano-gold, a molybdenum disulfide nanosheet, an amino-functionalized silicon dioxide nanomaterial, and an sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate, which are sequentially fixed on an electrode surface, coenzyme A, zirconium dioxide, biotin modified double-stranded DNA and avidin-modified beta -galactosidase, where one DNA strand is modified with a phosphate having a sequence and another DNA strand is modified with biotin. USE - Photoelectrochemical sensor for detecting histone acetyltransferase (claimed). DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method for preparing a photoelectrochemical sensor, which involves pretreating the electrode, adding graphene-nanogold, molybdenum disulfide nanosheets and silicon dioxide-ammonia to deionized water and dispersed by ultrasonication to obtain a dispersion, dispersing the graphene-nanogold dispersion, molybdenum disulfide nanosheet dispersion and silicon dioxide-ammonia and drying onto the surface of the electrode after pretreatment, adding sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate solution dropwise to the surface of the electrode treated at room temperature and humidity for 0.5-3 hour, washing and the histone acetyltransferase catalyzes the catalytic reaction droplets after the substrate peptide is acetylated, adding to the surface of the electrode and reacting at room temperature and humidity for 0.5-3 hour, adding zirconium dioxide to deionized water, ultrasonically dispersed to obtain a zirconium dioxide dispersion, adding zirconium dioxide dispersion to the surface of the electrode treated and reacted at room temperature and humidity for 0.5-3 hour, adding the biotin-modified double-stranded DNA solution dropwise to the surface of the electrode treated and reacted at 25-40 degrees C under humid conditions for 0.5-3 hour, adding avidin-modified mu -galactosidase solution dropwise to the surface of the electrode and reacting at 15-40 degrees C for 2-7 hours under humid conditions to obtain the finished product.