• 专利标题:   Conductive injectable hydrogel is prepared by mixing polyethylene glycol diacrylate-melamine crosslinker, hyaluronic acid having sulfhydryl group and graphene oxide, and performing Michael addition reaction to form crosslinked network.
  • 专利号:   CN107987285-A
  • 发明人:   WANG W, BAO R, LIU W
  • 专利权人:   UNIV TIANJIN
  • 国际专利分类:   C08J003/075, C08G081/00, C08K003/04, C08L087/00
  • 专利详细信息:   CN107987285-A 04 May 2018 C08J-003/075 201846 Pages: 11 Chinese
  • 申请详细信息:   CN107987285-A CN10986178 09 Nov 2016
  • 优先权号:   CN10986178

▎ 摘  要

NOVELTY - A conductive injectable hydrogel is prepared by mixing polyethylene glycol diacrylate-melamine crosslinker, hyaluronic acid having sulfhydryl group and graphene oxide, performing Michael addition reaction using a double bond on polyethylene glycol diacrylate-melamine and a sulfhydryl group on hyaluronic acid in an aqueous environment to form a crosslinked network in which doped graphene oxide is uniformly dispersed. The crosslinker reacts by using a carbon-carbon double bond at both ends of the polyethylene glycol diacrylate and hydrogen on the amine group in the melamine molecule. Hydrogen on each amine group reacts with one end carbon-carbon double bond of a polyethylene glycol diacrylate molecule, to chemically bond one melamine to six polyethylene glycol diacrylate molecules, to form a crosslinked network structure (I). The mass ratio of the crosslinker, hyaluronic acid and graphene oxide is (1.25-5):(3.5-4):(0.5-1), preferably (4-5):(3.5-4):(0.5-1). USE - Conductive injectable hydrogel. ADVANTAGE - The conductive injectable hydrogel can be prepared by a simple process using wide range of raw materials. The gelation time of the hydrogel can be changed by adjusting the amount of the crosslinking agent. By adjusting the addition of graphene oxide, the mechanical properties and electroconductivity of the hydrogel can be improved. DETAILED DESCRIPTION - The crosslinked network structure is of formula (I). n = polymerization degree. An INDEPENDENT CLAIM is included for preparation of conductive injectable hydrogel.