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  • 专利标题:   Detecting nucleic acid, e.g. SARS-CoV-2N gene, SARS-CoV-2E gene, HPV-16, HPV-18, involves using field effect transistors to amplify detection signal of Cas13a/Cas12a trans-cleavage in solution.
  • 专利号:   CN114150089-A
  • 发明人:   ZHANG X, WANG Q, JING Q, QIN Y, FU W
  • 专利权人:   UNIV TSINGHUA
  • 国际专利分类:   C12Q001/6837, C12Q001/70
  • 专利详细信息:   CN114150089-A 08 Mar 2022 C12Q-001/70 202238 Chinese
  • 申请详细信息:   CN114150089-A CN11543506 16 Dec 2021
  • 优先权号:   CN11543506

▎ 摘　　要

NOVELTY - Detecting nucleic acid involves using field effect transistors to amplify the detection signal of clustered regularly interspaced short palindromic repeats (CRISPR) -associated enzyme (Cas) 13a/Cas12a trans-cleavage in solution. USE - Method for detecting nucleic acid, where the detected object can be selected from severe acute respiratory syndrome coronavirus(SARS-CoV) 2N gene, SARS-CoV-2E gene, SARS-CoV-2Orf1ab gene, human papillomavirus (HPV) 16 or HPV-18 (claimed). ADVANTAGE - The method enables improving nucleic acid detection sensitivity.