▎ 摘　　要

NOVELTY - Pharmaceutical composition comprises 10-15 pts. wt. nanoparticles, 5-8 pts. wt. hydrogel, 3-5 pts. wt. particle capsule containing pharmaceutical agent, 10-15 pts. wt. polymer film, 2-5 pts. wt. liposome and solvent adjuvant. USE - The composition is used for glioma antibodies and glioma antibody drug carriers. ADVANTAGE - The composition achieves the rapid input of combined drug properties, realizes the differential release kinetics of drug molecules in acidic environment of cancerous tissue through movement of micropores under load of drug molecules in polymer film, promotes the pharmacokinetics through modification of nanoparticles, quickly releases sodium alginate on skin surface, inhibits the proliferation of cancer cells through its own antioxidant capacity and long-term differential slow release, combines the inhibitor on porous nanopolymer film through covalent reaction, shows excellent enzymatic hydrolysis performance due to confinement effect of micro-nanopores, and ensures excellent stability, which effectively improves biocompatibility. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing pharmaceutical composition, involving (a) preparing front-end polymer is obtained by droplet micro-fluidic technology and reversible addition-fragmentation chain transfer controllable free radical polymerization method, and porous polymer film with multi-micro-nano pore structure prepared by adding corresponding foaming agent, (b) adding inhibitor to surface of prepared polymer film, and polymerizing nanoparticles in pores of porous polymer thin film through covalent reaction combined nanoparticles, (c) adding modified nanoparticles and loading the nanoparticles to pores of porous polymer film by microwave treatment, and washing and crosslinking using solvent to obtain polymer transdermal substrate, (d) soaking microcapsule capsule in histone deacetylase inhibitor, using histone deacetylase inhibitor for permeating to microcapsule opening, soaking microcapsule capsule in liposome for coating lipid membrane, and heating lipid membrane to solidification seal, and (e) scraping solidified microcapsule capsule on top of polymer transdermal substrate loaded with particles, and scraping hydrogel waterproof and dustproof cover layer on surface of microcapsule capsule, and scraping the base membrane by film laminating machine, leaving for hydrogel for solidifying to film, cutting the vacuum bagging after cutting, and completing the preparation of transdermal patch.