• 专利标题:   Preparation of chitosan crosslinked graphene oxide composite sponge, includes dissolving chitosan in water containing acid, leaving to get chitosan solution, dissolving graphene oxide in water to obtain graphene oxide solution, adding glutaraldehyde for crosslinking, centrifuging, and freeze-drying.
  • 专利号:   CN115926245-A
  • 发明人:   LI T, XUE T, YE T, HAN P, ZHU X, WU Z, GAN H, SUN W, SUN Y, LIU S, DOU G, YANG L, MENG Z, GU R
  • 专利权人:   ACAD MILITARY MEDICAL SCI PLA
  • 国际专利分类:   A61L015/18, A61L015/28, A61L015/42, C08J009/28, C08K003/04, C08L005/08
  • 专利详细信息:   CN115926245-A 07 Apr 2023 C08J-009/28 202341 Chinese
  • 申请详细信息:   CN115926245-A CN10011272 05 Jan 2023
  • 优先权号:   CN10011272

▎ 摘  要

NOVELTY - A preparation method of chitosan crosslinked graphene oxide composite sponge comprises (S1) dissolving chitosan in water containing 1-2 %mass acid, stirring, leaving for 8-12 hours to obtain chitosan solution, weighing graphene oxide according to the ratio of 20-60% of the chitosan mass, dissolving it in water with the same volume as the chitosan solution ultrasonically, and leaving it for 8-12 hours to obtain a graphene oxide solution, (S2) mixing equal volumes of the chitosan solution and the graphene oxide solution, adding glutaraldehyde for crosslinking reaction, centrifuging and washing to obtain chitosan crosslinked graphene oxide, and (S3) dissolving the chitosan crosslinked graphene oxide in deionized water containing 1-2 %mass acid to obtain a chitosan crosslinked graphene oxide composite solution, pre-freezing and freeze-drying the chitosan crosslinked graphene oxide composite solution to obtain the finished product. USE - The method is used for preparing chitosan crosslinked graphene oxide composite sponge, which is used for preparing hemostatic material. (all claimed). ADVANTAGE - The method improves the shortcomings of chitosan and graphene oxide used alone, and provides theoretical support and ideas for the synthesis of new composite hemostatic materials. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: a chitosan crosslinked graphene oxide composite sponge prepared by the preparation method; and a hemostatic material comprising the chitosan crosslinked graphene oxide composite sponge as active component.