▎ 摘　　要

NOVELTY - Preparation of black phosphorus-graphene composite nano-contrast agent involves (a) adding black phosphorus graphene nanosheets or black phosphorus graphene quantum dot dispersion liquid (A) to graphene oxide nanosheet dispersion liquid (B) and uniformly mixing to form mixed dispersion liquid, (b) adding magnetic nanoparticles or magnetic nanoparticle precursor to mixed dispersion liquid to obtain mixed solution, (c) ultrasonically atomizing mixed solution to obtain ultrasonically atomized gas, and (d) heat-treating ultrasonically atomized gas under nitrogen or argon atmosphere. USE - Method is useful for preparing black phosphorus-graphene composite nano-contrast agent, which is useful in acupuncture research application (all claimed) and for targeted contrast imaging of deeper tissue. ADVANTAGE - The black phosphorus-graphene composite nano-contrast agent has excellent water solubility and magnetic and infrared photoacoustic response capability. DETAILED DESCRIPTION - Preparation method of black phosphorus-graphene composite nano-contrast agent involves (a) adding black phosphorus graphene nanosheets or black phosphorus graphene quantum dot dispersion liquid (A) to graphene oxide nanosheet dispersion liquid (B) and uniformly mixing to form mixed dispersion liquid, (b) adding magnetic nanoparticles or magnetic nanoparticle precursor to the mixed dispersion liquid to obtain mixed solution, (c) ultrasonically atomizing the mixed solution to obtain ultrasonically atomized gas, and (d) heat-treating the ultrasonically atomized gas under nitrogen or argon atmosphere. The dispersion liquid (A) and dispersion liquid (B) use same solvent. The volume ratio of dispersion liquid (A) and dispersion liquid (B) is 1-10:1. The concentration of dispersion liquid (A) and dispersion liquid (B) is 0.01-1 mg/m. The concentration of magnetic nanoparticles or magnetic nanoparticle precursor is 1-10 mg/ml. An INDEPENDENT CLAIM is included for black phosphorus-graphene composite nano-contrast agent prepared by the method.