• 专利标题:   Method for preparing three-dimensional network composite material for use in biological tissue engineering scaffold, involves using foamed nickel as raw material and depositing composite graphene on foamed nickel.
  • 专利号:   CN108653802-A
  • 发明人:   YAO Q, ZHENG X, LIU Y, CHENG R, LIN M
  • 专利权人:   UNIV WENZHOU MEDICAL
  • 国际专利分类:   A61L027/08, A61L027/12, A61L027/56, A61L027/58
  • 专利详细信息:   CN108653802-A 16 Oct 2018 A61L-027/08 201902 Pages: 16 Chinese
  • 申请详细信息:   CN108653802-A CN10401407 28 Apr 2018
  • 优先权号:   CN10401407

▎ 摘  要

NOVELTY - A three-dimensional network composite material preparing method involves using foamed nickel as a raw material and depositing composite graphene on the foamed nickel by a chemical vapor deposition method using a carbon-carbon gas as a carbon source under a reducing protective atmosphere to obtain a foamed nickel graphene composite material. The foamed nickel graphene composite material is dropped into a polymethyl methacrylate, dried and removed foamed nickel with a strong acid to obtain a graphene-polymethyl methacrylate composite material. The graphene-polymethyl methacrylate composite scaffold material is immersed in acetone to remove polymethyl methacrylate to obtain a graphene-based body having a three-dimensional porous structure, followed by using tetraethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, tetraethyl orthosilicate and triethyl phosphate, spin-coating and freeze-drying to obtain the finished product. USE - Method for preparing three-dimensional network composite material for use in biological tissue engineering scaff (claimed). DETAILED DESCRIPTION - A three-dimensional network composite material preparing method involves using foamed nickel as a raw material and depositing composite graphene on the foamed nickel by a chemical vapor deposition method using a carbon-carbon gas as a carbon source under a reducing protective atmosphere to obtain a foamed nickel graphene composite material. The foamed nickel graphene composite material is dropped into a polymethyl methacrylate, dried and removed foamed nickel with a strong acid to obtain a graphene-polymethyl methacrylate composite material. The graphene-polymethyl methacrylate composite scaffold material is immersed in acetone to remove polymethyl methacrylate to obtain a graphene-based body having a three-dimensional porous structure, followed by using tetraethyl orthosilicate as silicon source, triethyl phosphate as phosphorus source, calcium nitrate tetrahydrate as calcium source, tetraethyl orthosilicate and triethyl phosphate hydrolysis under water catalysis, hydrolysis in water/ethanol solution to form 58S BG precursor sol, adding dropwise to graphene-based body, spin-coating and freeze-drying to obtain a three-dimensional network composite semi-finished product of graphene and 58S bioactive glass and sintering in a tube furnace to obtain the finished product. An INDEPENDENT CLAIM is also included for a three-dimensional network composite based on graphene and 58S bioactive glass comprises graphene and 58S bioactive glass, where the graphene has a three-dimensional porous structure, and the 58S bioactive glass is spin-coated on the surface of the graphene structure in the form of a 58S bioactive glass precursor sol and sintering.